Wu Min, Li Lei, Yu Xuefeng, Zhang Daquan, Sun Tianying, Li Xue, Sun Ling, Lui Su, Huang Xiaoqi, Bi Feng, Wang Huaiyu, Zhu Hongyan, Gong Qiyong
J Biomed Nanotechnol. 2014 Dec;10(12):3620-30. doi: 10.1166/jbn.2014.2035.
The commonly used clinical magnetic resonance imaging (MRI) contrast agents are generally suitable for MR systems with a magnetic field less than 3.0 T. However, these agents show low contrast efficacy for MR systems with ultrahigh fields ≥ 7.0 T, which is the direction that next-generation MRI scanners are heading. A new contrast agent consisting of layered gadolinium hydroxide nanoplates doped with Ce and Tb (LGdH:Ce,Tb NPs) is presented herein. This material exhibits excellent negative (T2) contrast agent efficacy for 7.0 T MRI with a high r2/r1 ratio of 48.80, whereas it exhibits a lower r2/r1 ratio of 30.60 for 3.0 T MRI. Its performance as a T2 contrast agent in ultrahigh field MRI of subcutaneous liver tumor-bearing nude mice is investigated, demonstrating its ability to be used as a negative target T2 contrast agent to distinguish hepatic carcinoma from healthy tissues. Furthermore, the multifunctionality of the LGdH:Ce,Tb NPs as a contrast agent in X-ray computed tomography (CT) and fluorescence bioimaging is also presented, suggesting the possibility of integrating these imaging technologies for in-depth exploration of bioimaging.
常用的临床磁共振成像（MRI）造影剂通常适用于磁场强度小于3.0 T的MR系统。然而，对于下一代MRI扫描仪所朝向的超高场强≥7.0 T的MR系统，这些造影剂的对比效能较低。本文介绍了一种由掺杂Ce和Tb的层状氢氧化钆纳米片组成的新型造影剂（LGdH:Ce,Tb NPs）。这种材料在7.0 T MRI中表现出优异的负性（T2）造影剂效能，r2/r1比率高达48.80，而在3.0 T MRI中r2/r1比率较低，为30.60。研究了其在皮下荷肝癌裸鼠超高场MRI中作为T2造影剂的性能，证明了其作为负性靶向T2造影剂区分肝癌组织与健康组织的能力。此外，还介绍了LGdH:Ce,Tb NPs作为造影剂在X射线计算机断层扫描（CT）和荧光生物成像中的多功能性，这表明整合这些成像技术用于深入探索生物成像的可能性。
