静脉注射吲哚菁绿会导致脉搏血氧饱和度仪出现人为的短暂性氧饱和度降低。
Intravenous injection of indocyanine green results in an artificial transient desaturation by pulse oximetry.
作者信息
Ediriwickrema Lilangi S, Francis Jasmine H, Arslan-Carlon Vittoria, Dalecki Paul H, Brodie Scott E, Marr Brian P, Abramson David H
机构信息
*Ophthalmic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York; †Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California; ‡Department of Ophthalmology, Weill-Cornell Medical Center, New York, New York; §Department of Anesthesiology and Critical Care, Memorial Sloan Kettering Cancer Center, New York, New York; and ¶Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York.
出版信息
Retin Cases Brief Rep. 2015 Summer;9(3):252-5. doi: 10.1097/ICB.0000000000000152.
PURPOSE
To describe a case series of transient oxygen desaturation measured by pulse oximetry during the intravenous infusion of indocyanine green to enhance transpupillary thermotherapy in treating retinoblastoma after ophthalmic artery chemosurgery.
METHODS
Retrospective descriptive case series.
RESULTS
The intravenous administration of indocyanine green for ophthalmic angiography resulted in a transient drop in oxygen saturation as measured by Nellcor fingertip pulse oximetry in three children with retinoblastoma receiving indocyanine green-guided transpupillary thermotherapy. The magnitude of reduction ranged from 92% to 94% from an initial reading of 99% to 100% in each case, with an average duration of 3 minutes. Concurrent measurement of blood pressure, pulse, and expired CO2 showed no changes during this process.
CONCLUSION
Administration of intravenous indocyanine green resulted in a transient desaturation by oximetry during transpupillary thermotherapy for children with retinoblastoma under anesthesia because of the fluorescent dye's absorption of red light in a manner similar to that of deoxygenated hemoglobin, thereby leading to transient instrument misinterpretation and miscalculation of arterial oxygenation.
目的
描述一系列在静脉输注吲哚菁绿以增强经瞳孔温热疗法治疗视网膜母细胞瘤（在眼动脉化疗术后）过程中，通过脉搏血氧饱和度仪测得的短暂性氧饱和度下降的病例。
方法
回顾性描述性病例系列。
结果
在3例接受吲哚菁绿引导下经瞳孔温热疗法的视网膜母细胞瘤患儿中，静脉注射用于眼科血管造影的吲哚菁绿后，经Nellcor指尖脉搏血氧饱和度仪测量发现氧饱和度出现短暂下降。每例患儿的氧饱和度从初始读数99%至100%下降至92%至94%，平均持续时间为3分钟。在此过程中，同时测量的血压、脉搏和呼出二氧化碳均无变化。
结论
静脉注射吲哚菁绿导致接受麻醉的视网膜母细胞瘤患儿在经瞳孔温热疗法期间通过血氧测定法出现短暂性氧饱和度下降，这是因为这种荧光染料吸收红光的方式与脱氧血红蛋白相似，从而导致仪器对动脉氧合的短暂误判和误算。
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