静脉注射吲哚菁绿可能导致近红外脑氧饱和度测定读数出现假性升高。
Intravenously administered indocyanine green may cause falsely high near-infrared cerebral oximetry readings.
作者信息
Yoo Kyung Y, Baek Ho Y, Jeong Seongtae, Hallacoglu Bertan, Lee JongUn
机构信息
Departments of *Anesthesiology and Pain Medicine ‡Physiology, Chonnam National University Medical School, Gwangju, South Korea †Cephalogics, LLC, Cambridge, MA.
出版信息
J Neurosurg Anesthesiol. 2015 Jan;27(1):57-60. doi: 10.1097/ANA.0000000000000084.
BACKGROUND
Near-infrared spectroscopy assesses cerebral tissue oxygen saturation (Scto2) based on the absorption spectra of oxygenated and deoxygenated hemoglobin. It has been reported that IV-administered dyes including methylene blue, indigo carmine, and indocyanine green (ICG) may cause falsely low-pulse oximetry readings (Spo2). Although methylene blue and indigo carmine may also decrease Scto2, the effect of ICG has not been documented.
METHODS
Simultaneous changes in the heart rate, arterial blood pressure, Scto2, and Spo2 were measured after IV administration of ICG (12.5 mg diluted in 5.0 mL 0.9% NaCl) in 15 patients undergoing carotid endarterectomy under sevoflurane-remifentanil anesthesia.
RESULTS
After the dye administration, no change in heart rate or arterial blood pressure was observed in any patient. Scto2 increased by 13.3±4.0 percentage points, reaching the peak at 42.0±28.4 seconds after the administration, whereas Spo2 decreased by 1.9±1.2 percentage points, reaching the peak at 64.0±42.5 seconds (P<0.0001 both).
CONCLUSIONS
ICG falsely increases the spectroscopy-determined cerebral oxygen saturation for up to 12 minutes but dampens pulse oximetry readings.
背景
近红外光谱法基于氧合血红蛋白和脱氧血红蛋白的吸收光谱来评估脑组织氧饱和度（Scto2）。据报道，静脉注射包括亚甲蓝、靛胭脂和吲哚菁绿（ICG）在内的染料可能会导致脉搏血氧饱和度（Spo2）读数出现假性降低。虽然亚甲蓝和靛胭脂也可能降低Scto2，但ICG的影响尚无文献记载。
方法
在15例接受七氟醚-瑞芬太尼麻醉下行颈动脉内膜切除术的患者中，静脉注射ICG（12.5 mg溶于5.0 mL 0.9%氯化钠溶液）后，同时测量心率、动脉血压、Scto2和Spo2的变化。
结果
注射染料后，所有患者的心率和动脉血压均未发生变化。Scto2增加了13.3±4.0个百分点，在注射后42.0±28.4秒达到峰值，而Spo2降低了1.9±1.2个百分点，在64.0±42.5秒达到峰值（两者P<0.0001）。
结论
ICG会使光谱法测定的脑氧饱和度假性升高长达12分钟，但会降低脉搏血氧饱和度读数。
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