Camazine Maraya N, Hemmila Mark R, Leonard Julie C, Jacobs Rachel A, Horst Jennifer A, Kozar Rosemary A, Bochicchio Grant V, Nathens Avery B, Cryer Henry M, Spinella Philip C
From the Divisions of Critical Care (M.N.C., R.A.J., P.C.S.) and Emergency Medicine (J.A.H.), Department of Pediatrics, Washington University in St. Louis, St. Louis, Missouri; Department of Surgery (M.R.H.), University of Michigan Medical School, Ann Arbor, Michigan; Department of Pediatrics (J.C.L.), Nationwide Children's Hospital, Columbus, Ohio; Shock Trauma Center (R.A.K.), University of Maryland, Baltimore, Maryland; Department of Surgery (G.V.B.), Washington University in St. Louis, St. Louis, Missouri; Department of Surgery (A.B.N.), Sunnybrook Health Sciences Center and the University of Toronto, Toronto, Ontario, Canada; and Department of Surgery (H.M.C.), University of California, Los Angeles, Los Angeles, California.
J Trauma Acute Care Surg. 2015 Jun;78(6 Suppl 1):S48-53. doi: 10.1097/TA.0000000000000641.
Massive transfusion protocols (MTPs) have been developed to implement damage control resuscitation (DCR) principles. A survey of MTP policies from American College of Surgeons Trauma Quality Improvement Program (ACS-TQIP) participants was performed to establish which MTP activation, hemostatic resuscitation, and monitoring aspects of DCR are included in the MTP guidelines.
On October 10, 2013, ACS-TQIP administration administered a cross-sectional electronic survey to 187 ACS-TQIP participants.
Seventy-one percent (132 of 187) of responses were analyzed, with 62% designated as Level I and 38% designated as Level II ACS-TQIP trauma centers. Sixty-nine percent of sites indicated that they have plasma immediately available for MTP activation. By policy, in the first group of blood products administered, 88% of sites target high (≥1:2) plasma-to-red blood cell (RBC) ratios and 10% target low ratios. Likewise, 79% of sites target high platelet-to-RBC ratios and 16% target low ratios. Eighteen percent of sites reported incorporating point-of-care thromboelastogram into MTP policies. The most common intravenous hemostatic adjunct incorporated into MTPs was tranexamic acid (49%). Thirty-four percent of sites reported that some or all of their emergency medical service agencies have the ability to administer blood products or hemostatic agents during prehospital transport. There were minimal differences in MTP policies or capabilities between Level I and II sites.
The majority of ACS-TQIP participants reported having MTPs that support the use of DCR principles including high plasma-to-RBC and platelet-to-RBC ratios. Immediate availability of plasma and product use by emergency medical services are becoming increasingly common, whereas the incorporation of point-of-care thromboelastogram into MTP policies remains low.
大规模输血方案(MTPs)已被制定以实施损伤控制复苏(DCR)原则。对美国外科医师学会创伤质量改进项目(ACS-TQIP)参与者的MTP政策进行了一项调查,以确定MTP指南中包含了哪些DCR的MTP激活、止血复苏和监测方面。
2013年10月10日,ACS-TQIP管理部门对187名ACS-TQIP参与者进行了一项横断面电子调查。
分析了71%(187份中的132份)的回复,其中62%被指定为I级,38%被指定为II级ACS-TQIP创伤中心。69%的机构表示他们有血浆可立即用于MTP激活。根据政策,在首批输注的血液制品中,88%的机构目标是高(≥1:2)血浆与红细胞(RBC)比例,10%的机构目标是低比例。同样,79%的机构目标是高血小板与RBC比例,16%的机构目标是低比例。18%的机构报告将床旁血栓弹力图纳入MTP政策。纳入MTPs的最常见静脉止血辅助药物是氨甲环酸(49%)。34%的机构报告说他们的一些或所有紧急医疗服务机构有能力在院前运输期间输注血液制品或止血剂。I级和II级机构之间的MTP政策或能力差异极小。
大多数ACS-TQIP参与者报告拥有支持使用DCR原则的MTPs,包括高血浆与RBC以及血小板与RBC比例。血浆的即时可用性和紧急医疗服务对产品的使用越来越普遍,而将床旁血栓弹力图纳入MTP政策的情况仍然很少。