Sakamoto Yuichiro, Koami Hiroyuki, Miike Toru
Department of Emergency and Critical Care Medicine, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga City, Saga, 849-8501, Japan.
J Intensive Care. 2017 Jan 20;5(1):7. doi: 10.1186/s40560-016-0198-4.
Coagulopathy is a physiological response to massive bleeding that frequently occurs after severe trauma and is an independent predictive factor for mortality. Therefore, it is very important to grasp the coagulation status of patients with severe trauma quickly and accurately in order to establish the therapeutic strategy. Judging from the description in the European guidelines, the importance of viscoelastic devices in understanding the disease condition of patients with traumatic coagulopathy has been widely recognized in Europe. In the USA, the ACS TQIP Massive Transfusion in Trauma Guidelines proposed by the American College of Surgeons in 2013 presented the test results obtained by the viscoelastic devices, TEG® 5000 and ROTEM®, as the standard for transfusion or injection of blood plasma, cryoprecipitate, platelet concentrate, or anti-fibrinolytic agents in the treatment strategy for traumatic coagulopathy and hemorrhagic shock. However, some studies have reported limitations of these viscoelastic devices. A review in the Cochrane Library published in 2015 pointed out the presence of biases in the abovementioned reports in trauma patients and the absence of a quality study in this field thus far. A quality study on the relationship between traumatic coagulopathy and viscoelastic devices is needed.
凝血功能障碍是对严重创伤后经常发生的大量出血的一种生理反应,并且是死亡率的一个独立预测因素。因此,快速准确地掌握严重创伤患者的凝血状态对于制定治疗策略非常重要。从欧洲指南中的描述来看,黏弹性检测设备在了解创伤性凝血病患者病情方面的重要性在欧洲已得到广泛认可。在美国,美国外科医师学会于2013年提出的《美国外科医师学会创伤质量改进计划(ACS TQIP)创伤大量输血指南》将黏弹性检测设备TEG® 5000和ROTEM®所获得的检测结果作为创伤性凝血病和失血性休克治疗策略中输注血浆、冷沉淀、血小板浓缩物或抗纤溶药物的标准。然而,一些研究报告了这些黏弹性检测设备存在的局限性。2015年发表在《考克兰系统评价数据库》上的一篇综述指出上述创伤患者报告中存在偏倚,并且迄今为止该领域尚无高质量研究。因此需要开展一项关于创伤性凝血病与黏弹性检测设备之间关系的高质量研究。