The Goldring Center for Culinary Medicine, Tulane University, 1430 Tulane Avenue No. 8541, New Orleans, LA 70112, USA; Department of Global Health Systems & Development, Tulane University School of Public Health & Tropical Medicine, 1440 Canal Street, Suite 1900, Box TB-46, New Orleans, LA 70112, USA.
The Goldring Center for Culinary Medicine, Tulane University, 1430 Tulane Avenue No. 8541, New Orleans, LA 70112, USA.
Diabetes Res Clin Pract. 2015 Aug;109(2):420-6. doi: 10.1016/j.diabres.2015.05.007. Epub 2015 May 12.
A medical school-based teaching kitchen sought to establish proof-of-principle for its hands-on Mediterranean diet (MD)-based cooking and nutrition curriculum for patients with type 2 diabetes (T2D).
This pilot randomized controlled trial (RCT) allocated 27 patients with T2D between the control and GCCM arms. Mixed effects linear regression with repeated measures was used to investigate differences from baseline to 6 months. The primary and secondary endpoints were HbA1c -0.3% (-27 mmol/mol) and diastolic blood pressure (DBP) -10 mmHg and a 25% improved responses in dietary habits and attitudes and competencies in healthy nutrition.
Compared to the control group, the GCCM group had superior HbA1c reduction (-0.4% vs. -0.3%, p = 0.575) that was not statistically significant. There were significantly greater reductions in the GCCM vs. control group for DBP (-4 vs. 7 mmHg, p=0.037) and total cholesterol (-14 vs. 17 mg/dL, p = 0.044). There was a greater proportion increase though not significant of GCCM subjects compared to controls who mostly believed they could eat correct portions (18% vs. -11%, p = 0.124), and who used nutrition panels to make food choices (34% vs. 0%, p = 0.745).
This is the first known RCT demonstrating improved biometrics using a novel MD-based hands on cooking and nutrition curriculum for patients with T2D. These results suggest subsequent clinical trials are warranted on the grounds of documented feasibility and clinical efficacy.
医学院设立了一个教学厨房,旨在为 2 型糖尿病(T2D)患者提供基于实践的地中海饮食(MD)烹饪和营养课程,以此验证其原理。
这项试点随机对照试验(RCT)将 27 名 T2D 患者分配到对照组和 GCCM 组。采用重复测量混合效应线性回归分析来研究从基线到 6 个月的差异。主要和次要终点分别为 HbA1c 降低 0.3%(-27mmol/mol)和舒张压(DBP)降低 10mmHg,以及饮食习惯和态度以及健康营养方面的能力有 25%的改善。
与对照组相比,GCCM 组的 HbA1c 降低更显著(-0.4%比-0.3%,p=0.575),但无统计学意义。GCCM 组的 DBP(-4mmHg 比-7mmHg,p=0.037)和总胆固醇(-14mg/dL 比-17mg/dL,p=0.044)降低幅度明显更大。尽管没有统计学意义,但与对照组相比,GCCM 组中有更大比例的受试者认为自己可以正确进食(18%比-11%,p=0.124),并且使用营养面板来选择食物(34%比 0%,p=0.745)。
这是第一个已知的 RCT,证明了使用新型基于 MD 的实践烹饪和营养课程可改善 T2D 患者的生物标志物。这些结果表明,有必要进行后续的临床试验,以证明其已记录的可行性和临床疗效。