Buer Jonas Kure
Department of Social Anthropology, University of Oslo, Blindern, Postboks 1091, 0317, Oslo, Norway,
Inflammopharmacology. 2015 Aug;23(4):163-71. doi: 10.1007/s10787-015-0232-5. Epub 2015 May 23.
The article outlines a history of the concept of "disease-modifying antirheumatic drugs" or DMARDs--from the emergence in the 1970s of the idea of drugs with decisive long-term effects on bone erosion in rheumatoid arthritis (RA), through the consolidation and popularisation in the term DMARD in 1980s and 1990s. It then examines the usage of the terms "remission-inducing drugs" (RIDs) and "slow-acting anti-rheumatic drugs" (SAARDs), which for some years offered competition to the term DMARDs, thus underscoring the contingency of the establishment of DMARD as a word. Finally, it juxtaposes the apparently spontaneous emergence of the three terms DMARD, SAARD and RID, and the disappearance of the latter two, with a failed attempt in the early 1990s to replace these terms with the new term "disease-controlling antirheumatic treatment" (DC-ART). The analysis highlights the paradoxical qualities of the DMARD concept as robust albeit tension ridden, while playing down the role of identified individuals and overarching explanations of purpose.
本文概述了“改善病情抗风湿药”(DMARDs)这一概念的历史——从20世纪70年代出现对类风湿关节炎(RA)骨侵蚀有决定性长期作用的药物理念,到20世纪80年代和90年代“DMARDs”这一术语的巩固和普及。接着,文章审视了“诱导缓解药物”(RIDs)和“慢作用抗风湿药物”(SAARDs)这两个术语的使用情况,它们在若干年里与“DMARDs”这一术语相互竞争,从而凸显了“DMARDs”作为一个词汇确立的偶然性。最后,文章将“DMARDs”“SAARDs”和“RIDs”这三个术语看似自发的出现以及后两者的消失,与20世纪90年代初用新术语“疾病控制抗风湿治疗”(DC - ART)取代这些术语的失败尝试进行了对比。该分析突出了DMARD概念看似矛盾的特质,即尽管充满张力但却稳固,同时淡化了特定个体的作用以及对目的的总体解释。