非麻醉性非处方镇咳滥用药物的电化学分析测定的分类评价

A categorical review on electroanalytical determination of non-narcotic over-the-counter abused antitussive drugs.

机构信息

Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal (Westville Campus), Durban 4000, South Africa.

出版信息

Talanta. 2015 Sep 1;142:157-63. doi: 10.1016/j.talanta.2015.04.061. Epub 2015 Apr 29.

DOI:10.1016/j.talanta.2015.04.061

PMID:26003706

Abstract

Dextromethorphan (DXM) and diphenhydramine (DPH) are two commonly used over-the-counter non-narcotic antitussive drugs. Recent reports reveal the widespread abuse of DXM and DPH due to their euphoric and alcohol-like effects. Due to their medicinal importance as well as the apparent increase in their use as abused drugs, it has become critical to determine them in samples of biological, clinical and pharmaceutical interest. The electrochemical techniques for drug analysis have gathered considerable attention due to their pronounced selectivity, sensitivity and simplicity. The given review presents a compilation of published voltammetric and potentiometric methods developed for determination of DXM and DPH. It critically highlights the analytical performances, revealing the recent trends and progress in the specified approach for their analysis. The review forms a basis for further progress in this field and development of improved electrochemical sensors to determine the drug.

摘要

右美沙芬（DXM）和苯海拉明（DPH）是两种常用的非处方止咳药。最近的报告显示，由于其欣快和类似酒精的作用，DXM 和 DPH 被广泛滥用。由于它们具有医学重要性，以及作为滥用药物的使用明显增加，因此必须在生物、临床和制药相关的样本中对它们进行检测。由于电化学技术具有显著的选择性、灵敏度和简单性，因此它们在药物分析中受到了相当多的关注。本综述介绍了为测定 DXM 和 DPH 而开发的已发表的伏安法和电位法。它批判性地突出了分析性能，揭示了该分析方法的最新趋势和进展。该综述为该领域的进一步发展以及开发用于测定药物的改进型电化学传感器奠定了基础。