GDF11 和神秘的青春之泉。
GDF11 and the Mythical Fountain of Youth.
机构信息
Sprott Center for Stem Cell Research, Ottawa Hospital Research Institute, Regenerative Medicine Program, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada; Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada.
Sprott Center for Stem Cell Research, Ottawa Hospital Research Institute, Regenerative Medicine Program, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada; Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada.
出版信息
Cell Metab. 2015 Jul 7;22(1):54-6. doi: 10.1016/j.cmet.2015.05.009. Epub 2015 May 20.
Identifying candidates that rejuvenate aged muscle stem cells is an important strategy toward developing therapies to treat age-related diseases. In this issue, Egerman et al. (2015) re-investigate the activity of GDF11 in myogenesis, recently suggested as an anti-aging agent, and instead find a potent inhibitory effect on skeletal muscle regeneration.
鉴定能使衰老的肌肉干细胞再生的候选物是开发治疗与年龄相关疾病疗法的一个重要策略。在本期杂志中，Egerman 等人（2015 年）重新研究了 GDF11 在成肌中的活性，最近该物质被认为是一种抗衰老剂，但他们发现其对骨骼肌再生具有很强的抑制作用。
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