Prattichizzo Francesco, Giuliani Angelica, Sabbatinelli Jacopo, Mensà Emanuela, De Nigris Valeria, La Sala Lucia, de Candia Paola, Olivieri Fabiola, Ceriello Antonio
IRCCS MultiMedica, Milan, Italy.
Department of Clinical and Molecular Sciences, DISCLIMO, Università Politecnica delle Marche, Ancona, Italy.
J Extracell Vesicles. 2019 Aug 15;8(1):1656044. doi: 10.1080/20013078.2019.1656044. eCollection 2019.
Parabiosis experiments in mice demonstrated that a young environment could partially rejuvenate multiple tissues of old organisms. However, the circulating mediators responsible of such effect have been elusive so far. Novel results suggest that extracellular vesicles isolated from plasma of young mice increase lifespan in old mice. Here we integrate these findings in a larger framework, advancing the hypothesis that circulating vesicles may mediate the beneficial effect of a young on ageing.
小鼠联体共生实验表明，年轻环境可使老年生物体的多种组织部分恢复活力。然而，迄今为止，造成这种效应的循环介质仍不明确。新的研究结果表明，从小鼠血浆中分离出的细胞外囊泡可延长老年小鼠的寿命。在此，我们将这些发现整合到一个更大的框架中，提出循环囊泡可能介导年轻环境对衰老的有益作用这一假说。
