自发性糖尿病Torii（SDT）肥胖大鼠的骨形态学分析
Bone morphological analyses in Spontaneously Diabetic Torii (SDT) fatty rats.
作者信息
Ohta Takeshi, Kimura Shuichi, Hirata Masaya, Yamada Takahisa, Sugiyama Toshie
机构信息
Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
出版信息
J Vet Med Sci. 2015 Oct;77(10):1327-30. doi: 10.1292/jvms.15-0154. Epub 2015 May 22.
The Spontaneously Diabetic Torii (SDT) fatty rat, a model for obese type 2 diabetes, shows bone quantitative abnormalities, namely low bone mineral density (BMD). The objective of this study was to evaluate bone morphological changes, in particular identifying the bone qualitative abnormalities, in the SDT fatty rat. Male SDT fatty rats showed increases in total trabecular area and trabecular number and decreases in trabecular thickness in cancellous bones of the proximal tibia, indicating trabecular miniaturization. The SDT fatty rat is useful for investigation of pathophysiological changes in bone quality in diabetic osteoporosis.
自发性糖尿病Torii（SDT）肥胖大鼠是一种2型糖尿病模型，表现出骨骼定量异常，即低骨矿物质密度（BMD）。本研究的目的是评估SDT肥胖大鼠的骨骼形态变化，特别是识别骨骼定性异常。雄性SDT肥胖大鼠胫骨近端松质骨的总小梁面积和小梁数量增加，小梁厚度减小，表明小梁微型化。SDT肥胖大鼠有助于研究糖尿病性骨质疏松症中骨质量的病理生理变化。
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