大冢长- Evans 德岛肥胖大鼠的股骨结构
Femoral bone structure in Otsuka Long-Evans Tokushima Fatty rats.
作者信息
Minematsu Akira, Hanaoka Tomoko, Takada Yoshihiro, Okuda Shunji, Imagita Hidetaka, Sakata Susumu
机构信息
Department of Physical Therapy, Faculty of Health Science, Kio University, 4-2-2 Umaminaka, Koryo-cho, Kitakatsuragi-gun, Nara 635-0832, Japan.
Division of Health Science, Graduate School of Health Science, Kio University, 4-2-2 Umaminaka, Koryo-cho, Kitakatsuragi-gun, Nara 635-0832, Japan.
出版信息
Osteoporos Sarcopenia. 2016 Mar;2(1):25-29. doi: 10.1016/j.afos.2015.12.001. Epub 2016 Mar 14.
OBJECTIVES
Type 2 diabetes mellitus (T2DM) increases fracture risk despite normal to high levels of bone mineral density. Bone quality is known to affect bone fragility in T2DM. The aim of this study was to clarify the trabecular bone microstructure and cortical bone geometry of the femur in T2DM model rats.
METHODS
Five-week-old Otsuka Long-Evans Tokushima Fatty (OLETF; n = 5) and Long-Evans Tokushima Otsuka (LETO; n = 5) rats were used. At the age of 18 months, femurs were scanned with micro-computed tomography, and trabecular bone microstructure and cortical bone geometry were analyzed.
RESULTS
Trabecular bone microstructure and cortical bone geometry deteriorated in the femur in OLETF rats. Compared with in LETO rats, in OLETF rats, bone volume fraction, trabecular number and connectivity density decreased, and trabecular space significantly increased. Moreover, in OLETF rats, cortical bone volume and section area decreased, and medullary volume significantly increased.
CONCLUSIONS
Long-term T2DM leaded to deterioration in trabecular and cortical bone structure. Therefore, OLETF rats may serve as a useful animal model for investigating the relationship between T2DM and bone quality.
目的
2型糖尿病（T2DM）会增加骨折风险，即便骨矿物质密度处于正常至高值水平。已知骨质量会影响T2DM患者的骨脆性。本研究旨在阐明T2DM模型大鼠股骨的小梁骨微观结构和皮质骨几何形态。
方法
使用5周龄的大冢长- Evans德岛肥胖（OLETF；n = 5）大鼠和大冢长- Evans德岛（LETO；n = 5）大鼠。18月龄时，用微型计算机断层扫描对股骨进行扫描，并分析小梁骨微观结构和皮质骨几何形态。
结果
OLETF大鼠股骨的小梁骨微观结构和皮质骨几何形态恶化。与LETO大鼠相比，OLETF大鼠的骨体积分数、小梁数量和连通性密度降低，小梁间距显著增加。此外，OLETF大鼠的皮质骨体积和截面积减小，髓腔体积显著增加。
结论
长期T2DM导致小梁骨和皮质骨结构恶化。因此，OLETF大鼠可能是研究T2DM与骨质量之间关系的有用动物模型。
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