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苦杏仁胶和欧洲李胶在片剂制剂中的结合潜力比较研究。

Comparative studies of binding potential of Prunus armeniaca and Prunus domestica gums in tablets formulations.

作者信息

Rahim Haroon, Khan Mir Azam, Sadiq Abdul, Khan Shahzeb, Chishti Kamran Ahmad, Rahman Inayat U

机构信息

Department of Pharmacy, Sarhad University of Science and Information Technology Peshawar, Khyber Pakhtunkhwa, Pakistan.

Department of Pharmacy, University of Malakand, Chakdara, Khyber Pakhtunkhwa, Pakistan.

出版信息

Pak J Pharm Sci. 2015 May;28(3):909-14.


DOI:
PMID:26004724
Abstract

The current study was undertaken to compare the binding potential of Prunus armeniaca L. and Prunus domestica L. gums in tablets' formulations. Tablet batches (F-1 to F-9) were prepared Diclofenac sodium as model drug using 5%, 7.5% and 10% of each Prunus armeniaca L., Prunus domestica L. gums as binder. PVP K30 was used as a standard binder. Magnesium stearate was used as lubricant. Flow properties of granules (like bulk density, tapped density, Carr's index, Hausner's ratio, angle of repose) as well as the physical parameters of compressed tablets including hardness, friability, thickness and disintegration time were determined. Flow parameters of granules of all the batches were found good. Physical parameters (drug content, weight variation, thickness, hardness, friability, disintegration time) of formulated tablets were found within limit when tested. The dissolution studies showed that tablets formulations containing each Prunus domestica showed better binding capacity compared to Prunus armeniaca gum. The binding potential increased as the concentration of gums increased. The FTIR spectroscopic investigation showed that the formulations containing plant gum are compatible with the drug and other excipients used.

摘要

本研究旨在比较苦杏仁胶和西洋李胶在片剂配方中的结合潜力。以双氯芬酸钠为模型药物,使用5%、7.5%和10%的苦杏仁胶、西洋李胶作为粘合剂制备片剂批次(F-1至F-9)。聚乙烯吡咯烷酮K30用作标准粘合剂。硬脂酸镁用作润滑剂。测定颗粒的流动性质(如堆密度、振实密度、卡尔指数、豪斯纳比、休止角)以及压制片剂的物理参数,包括硬度、脆碎度、厚度和崩解时间。发现所有批次颗粒的流动参数良好。测试时,配方片剂的物理参数(药物含量、重量差异、厚度、硬度、脆碎度、崩解时间)均在限度内。溶出度研究表明,与苦杏仁胶相比,含有西洋李胶的片剂配方显示出更好的结合能力。随着胶浓度的增加,结合潜力增强。傅里叶变换红外光谱研究表明,含有植物胶的配方与所用药物和其他辅料相容。

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