State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou, China.
State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou, China.
Carbohydr Polym. 2015 Sep 5;128:105-11. doi: 10.1016/j.carbpol.2015.04.006. Epub 2015 Apr 15.
A new xylan ester (xylan 3,5-dinitrobenzoate) as a creatinine adsorbent was prepared by the homogeneous acylation of xylan with 3,5-dinitrobenzoyl chloride in 1-butul-3-methylimidazolium chloride ionic liquid. The influences of reaction conditions on the degree of substitution values of xylan esters were discussed. Results indicated that xylan esters with the degree of substitution range from 1.34 to 1.77 were obtained under the given conditions. The FTIR and (13)C NMR spectroscopies provided the evidence of grafting 3,5-dinitrobenzoyl groups onto the backbone of xylan. Moreover, the adsorption properties of the xylan ester for creatinine were also investigated. Isotherm studies showed that the sorption capacities for creatinine were 2.45, 2.08 and 1.86 mg/g for 23, 30 and 37 °C, respectively. Thermodynamic studies performed indicated the sorption process mainly was controlled by the chemical adsorption. Therefore, xylan 3,5-dinitrobenzoate displayed the promising application in the treatment of chronic renal failure by the creatinine adsorption as the new oral adsorbent.
一种新型木聚糖酯（3,5-二硝基苯甲酸木聚糖酯）作为肌酸酐吸附剂，是通过在 1-丁基-3-甲基咪唑氯盐离子液体中用 3,5-二硝基苯甲酰氯均匀酰化木聚糖而制备的。讨论了反应条件对木聚糖酯取代度值的影响。结果表明，在给定条件下可以得到取代度在 1.34 至 1.77 范围内的木聚糖酯。傅里叶变换红外光谱（FTIR）和（13）C 核磁共振光谱为在木聚糖主链上接枝 3,5-二硝基苯甲酰基提供了证据。此外，还研究了木聚糖酯对肌酸酐的吸附性能。等温线研究表明，23、30 和 37°C 时，肌酸酐的吸附容量分别为 2.45、2.08 和 1.86mg/g。热力学研究表明，吸附过程主要受化学吸附控制。因此，木聚糖 3,5-二硝基苯甲酸酯作为新型口服吸附剂，通过肌酸酐吸附，在治疗慢性肾功能衰竭方面显示出良好的应用前景。
