白细胞介素-6基因多态性与印度人群口腔鳞状细胞癌风险的关联。
Association of interleukin-6 genetic polymorphisms with risk of OSCC in Indian population.
作者信息
Singh Prithvi Kumar, Chandra Girish, Bogra Jaishri, Gupta Rajni, Kumar Vijay, Jain Amita, Hussain Syed Rizwan, Mahdi Abbas Ali, Ahmad Mohammad Kaleem
机构信息
Department of Anaesthesiology, King George's Medical University, Lucknow, India.
Department of Surgical Oncology, King George's Medical University, India.
出版信息
Meta Gene. 2015 May 15;4:142-51. doi: 10.1016/j.mgene.2015.03.002. eCollection 2015 Jun.
PURPOSE
Interleukin-6 (IL-6) encodes a cytokine protein, which causes inflammation, maintains immune homeostasis and plays an essential role in oral pathogenesis. The aim of this study was to evaluate the association between IL-6 (- 174 and - 572) G/C promoter gene polymorphisms and risk of OSCC among Indians.
METHODS
Single nucleotide polymorphism in IL-6 genes was genotyped in OSCC patients and healthy controls by PCR-RFLP method. Genotype and allele frequencies were analyzed by chi-square test and strength of associations by odds ratio with 95% confidence intervals.
RESULTS
Frequency distribution of IL-6 (- 174) G/C gene polymorphism was significantly associated with OSCC patients in comparison to healthy controls (OR: 0.541, CI: 0.356-0.822; p: 0.004. However, frequency of IL-6 (- 572) G/C gene polymorphism was not significantly associated with OSCC patients (p > 0.05).
CONCLUSION
The genotype GC and allele C of IL-6 (- 174) G/C gene polymorphism play a significant role in OSCC susceptibility.
目的
白细胞介素-6（IL-6）编码一种细胞因子蛋白，该蛋白可引发炎症、维持免疫稳态并在口腔发病机制中起重要作用。本研究旨在评估印度人群中IL-6（-174和-572）G/C启动子基因多态性与口腔鳞状细胞癌（OSCC）风险之间的关联。
方法
采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法对OSCC患者和健康对照者的IL-6基因进行单核苷酸多态性基因分型。通过卡方检验分析基因型和等位基因频率，并通过比值比及95%置信区间分析关联强度。
结果
与健康对照相比，IL-6（-174）G/C基因多态性的频率分布与OSCC患者显著相关（比值比：0.541，置信区间：0.356 - 0.822；p：0.004）。然而，IL-6（-572）G/C基因多态性的频率与OSCC患者无显著关联（p > 0.05）。
结论
IL-6（-174）G/C基因多态性的基因型GC和等位基因C在OSCC易感性中起重要作用。
Zotero 插件