白细胞介素17A和白细胞介素17F基因多态性与中国人群口腔鳞状细胞癌易感性相关。

Interleukin 17A and interleukin 17F polymorphisms are associated with oral squamous cell carcinoma susceptibility in a Chinese population.

作者信息

Li Ning, Zhang Chao, Chen Zhaoquan, Bai Lilu, Nie Min, Zhou Bin, Xu Huanxi

机构信息

Department of Stomatology, PetroChemical General Hospital of Lanzhou, Gansu, China.

Department of Stomatology, Shihua General Hospital of Lanzhou, Gansu, China.

出版信息

J Oral Maxillofac Surg. 2015 Feb;73(2):267-73. doi: 10.1016/j.joms.2014.09.009. Epub 2014 Sep 30.

DOI:10.1016/j.joms.2014.09.009

PMID:25579009

Abstract

PURPOSE

Several studies have investigated the association of the interleukin (IL) 17A and IL-17F polymorphisms and cancer of various organs. However, the role of the IL-17A and IL-17F polymorphisms in oral squamous cell carcinoma (OSCC) remains unclear. Thus we sought to clarify the association of the rs2275913, rs763780, and rs2397084 polymorphisms with OSCC in a Chinese population.

MATERIALS AND METHODS

A TaqMan single-nucleotide polymorphism Genotyping Assay (ABI, Foster, CA) was used to measure the distributions of the IL-17A (rs2275913) and IL-17F (rs763780, rs2397084) polymorphisms in 121 OSCC patients and 103 healthy controls. The association of those polymorphisms and clinical OSCC patient characteristic also was evaluated.

RESULTS

Individuals carrying the rs2275913 A allele and AA genotype had an increased risk of OSCC (odds ratio [OR], 1.463; 95% confidence interval [CI], 0.807 to 2.652; and OR, 2.713; 95% CI, 1.250 to 5.889, respectively). The frequency of the rs2397084 T allele was significantly associated with a higher risk of OSCC than the G allele (OR, 1.501; 95% CI, 1.026 to 2.196). No difference in rs763780 frequencies was observed. The rs2275913 AA and rs2397084 TT genotypes also were associated with late clinical stages and poor tumor differentiation. In addition, stratification analysis indicated that the rs2275913 AA genotype increased OSCC risk among smoking and drinking populations (OR, 4.000; 95% CI, 1.404 to 11.394; and OR, 3.500; 95% CI, 1.018 to 12.030, respectively). In a smoking population, an rs9382084 T-allele carrier has a greater potential risk of OSCC than the overall population (OR, 2.200; 95% CI, 1.009 to 4.797).

CONCLUSIONS

The results of this study suggest a significant association of rs2275913 and rs2397084 but not rs763780 with OSCC risk, and this was related to tumor stage and differentiation. In addition, the IL-17A and IL-17F polymorphisms can interact with smoking and drinking to enhance the risk of OSCC developing.

摘要

目的

多项研究调查了白细胞介素（IL）-17A和IL-17F基因多态性与各器官癌症的关联。然而，IL-17A和IL-17F基因多态性在口腔鳞状细胞癌（OSCC）中的作用仍不清楚。因此，我们试图阐明rs2275913、rs763780和rs2397084基因多态性与中国人群OSCC的关联。

材料与方法

采用TaqMan单核苷酸多态性基因分型检测法（ABI，福斯特，加利福尼亚州）测定121例OSCC患者和103例健康对照者中IL-17A（rs2275913）和IL-17F（rs763780、rs2397084）基因多态性的分布情况。还评估了这些基因多态性与OSCC患者临床特征的关联。

结果

携带rs2275913 A等位基因和AA基因型的个体患OSCC的风险增加（优势比[OR]分别为1.463；95%置信区间[CI]为0.807至2.652；以及OR为2.713；95% CI为1.250至5.889）。rs2397084 T等位基因的频率与OSCC风险显著相关，高于G等位基因（OR为1.501；95% CI为1.026至2.196）。未观察到rs763780频率的差异。rs2275913 AA和rs2397084 TT基因型也与临床晚期和肿瘤低分化相关。此外，分层分析表明，rs2275913 AA基因型在吸烟和饮酒人群中增加了OSCC风险（OR分别为4.000；95% CI为1.404至11.394；以及OR为3.500；95% CI为1.018至12.030）。在吸烟人群中，rs9382084 T等位基因携带者患OSCC的潜在风险高于总体人群（OR为2.200；95% CI为1.009至4.797）。