Cupisti Adamasco, Bottai Anna, Bellizzi Vincenzo, Brunori Giuliano, Cianciaruso Bruno, De Nicola Luca, Oldrizzi Lamberto, Quintaliani Giuseppe, Santoro Domenico, Di Iorio Biagio Raffaele
G Ital Nefrol. 2015 Mar-Apr;32(2).
Chronic kidney disease is acknowledged as one of the most relevant disease for public health. Knowledge of epidemiology of CKD may allow public health interventions both for prevention and treatment in order to limit burden and management costs. Nefrodata is a multicentric, prospective, and observational study conducted in Italy, including patients with CKD followed in a specialist setting. The study uses a web-based data setting; it includes 1263 subjects with an estimate glomerular filtration rate (eGFR) less than 60 ml/min *1,73 sqm, followed in outpatient clinics in Italy. Patients' characteristics analysis evidences that old subjects (mean age of 70.3 13.4 years, 55% of them older than 70 years), with cardiovascular morbidity (50,6%) and diabetics (37%) have a high prevalence. With the reduction of residual renal function, prevalence of hyperphospatemia, metabolic acidosis, use of erythropoiesis-stimulating agents, Vitamin D, and diuretics increases. Also allopurinol and gastric-protective drugs are widely used. Fifty-four and eight % of patients with CKD stage 4 and 65.9% of patients with CKD stage 5 received indication on nutritional therapy.
慢性肾脏病被公认为是对公众健康最具相关性的疾病之一。了解慢性肾脏病的流行病学情况有助于开展公共卫生干预措施,包括预防和治疗,以减轻负担和控制管理成本。Nefrodata是一项在意大利开展的多中心、前瞻性观察性研究,纳入了在专科环境中接受随访的慢性肾脏病患者。该研究采用基于网络的数据设置;纳入了1263名估计肾小球滤过率(eGFR)低于60 ml/min·1.73平方米的受试者,这些受试者在意大利的门诊接受随访。对患者特征的分析表明,老年受试者(平均年龄70.3±13.4岁,其中55%年龄超过70岁)、有心血管疾病(50.6%)和糖尿病(37%)的患者患病率较高。随着残余肾功能的下降,高磷血症、代谢性酸中毒、促红细胞生成素、维生素D和利尿剂的使用患病率增加。此外,别嘌醇和胃保护药物也被广泛使用。4期慢性肾脏病患者中有54%和8%以及5期慢性肾脏病患者中有65.9%接受了营养治疗的建议。