Maiti Nandita, Chadha Ridhima, Das Abhishek, Kapoor Sudhir
Radiation & Photochemistry Division, Bhabha Atomic Research Centre, Mumbai 400 085, India.
Radiation & Photochemistry Division, Bhabha Atomic Research Centre, Mumbai 400 085, India.
Spectrochim Acta A Mol Biomol Spectrosc. 2015;149:949-56. doi: 10.1016/j.saa.2015.05.043. Epub 2015 May 19.
Raman and surface-enhanced Raman scattering (SERS) studies of thioflavin T (ThT) in solid, solution, gold nanoparticles (GNPs), silver nanoparticles (SNPs) and silver-coated films (SCFs) were investigated. Concentration-dependent SERS spectrum of ThT in GNPs and SNPs indicated the existence of two possible structures, one with the torsional angle (φ) between benzothiazole and dimethylaminobenzene rings being 37° and the other with φ=90°. The SERS spectrum of ThT in SCFs were similar to the Raman spectrum of solid and solution that suggests φ=37°. In this paper, the high sensitivity of the SERS technique was employed for sub-nanomolar (picomolar) sensing of ThT.
研究了硫黄素T（ThT）在固体、溶液、金纳米颗粒（GNP）、银纳米颗粒（SNP）和镀银膜（SCF）中的拉曼光谱和表面增强拉曼散射（SERS）。ThT在GNP和SNP中的浓度依赖性SERS光谱表明存在两种可能的结构，一种是苯并噻唑环和二甲基氨基苯环之间的扭转角（φ）为37°，另一种是φ = 90°。ThT在SCF中的SERS光谱与固体和溶液的拉曼光谱相似，表明φ = 37°。本文利用SERS技术的高灵敏度对ThT进行亚纳摩尔（皮摩尔）传感。
