Cooch Nisha K, Stalnaker Thomas A, Wied Heather M, Bali-Chaudhary Sheena, McDannald Michael A, Liu Tzu-Lan, Schoenbaum Geoffrey
Department of Anatomy and Neurobiology, University of Maryland, School of Medicine, 20 Penn Street, Baltimore, Maryland 21201, USA.
National Institute on Drug Abuse Intramural Research Program, Cellular Neurobiology Research Branch, Behavioral Neurophysiology Research Section, 251 Bayview Boulevard, Baltimore, Maryland 21224, USA.
Nat Commun. 2015 May 21;6:7195. doi: 10.1038/ncomms8195.
The ventral striatum has long been proposed as an integrator of biologically significant associative information to drive actions. Although inputs from the amygdala and hippocampus have been much studied, the role of prominent inputs from orbitofrontal cortex (OFC) are less well understood. Here, we recorded single-unit activity from ventral striatum core in rats with sham or ipsilateral neurotoxic lesions of lateral OFC, as they performed an odour-guided spatial choice task. Consistent with prior reports, we found that spiking activity recorded in sham rats during cue sampling was related to both reward magnitude and reward identity, with higher firing rates observed for cues that predicted more reward. Lesioned rats also showed differential activity to the cues, but this activity was unbiased towards larger rewards. These data support a role for OFC in shaping activity in the ventral striatum to represent the biological significance of associative information in the environment.
长期以来，腹侧纹状体一直被认为是生物重要关联信息的整合者，以驱动行为。虽然来自杏仁核和海马体的输入已得到大量研究，但眶额叶皮质（OFC）突出输入的作用却了解较少。在此，我们记录了在进行气味引导空间选择任务时，接受假手术或同侧OFC外侧神经毒性损伤的大鼠腹侧纹状体核心的单神经元活动。与先前报告一致，我们发现假手术大鼠在线索采样期间记录到的放电活动与奖励大小和奖励类型均相关，对于预测更多奖励的线索，观察到更高的放电频率。损伤大鼠对线索也表现出不同的活动，但这种活动对更大奖励没有偏向性。这些数据支持OFC在塑造腹侧纹状体活动以表征环境中关联信息的生物学意义方面的作用。
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