Sato Kohei, Kitakaze Keisuke, Nakamura Takahiro, Naruse Naoto, Aihara Keisuke, Shigenaga Akira, Inokuma Tsubasa, Tsuji Daisuke, Itoh Kohji, Otaka Akira
Institute of Biomedical Sciences and Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima 770-8505, Japan.
Chem Commun (Camb). 2015 Jun 21;51(49):9946-8. doi: 10.1039/c5cc02967h.
We describe a novel peptide ligation/desulfurization strategy using a β-mercapto-N-glycosylated asparagine derivative. The newly developed procedure was successfully applied to the total chemical synthesis of the GM2 ganglioside activator protein bearing a monosaccharide on the native glycosylation site.
我们描述了一种使用β-巯基-N-糖基化天冬酰胺衍生物的新型肽连接/脱硫策略。新开发的方法成功应用于在天然糖基化位点带有单糖的GM2神经节苷脂激活蛋白的全化学合成。
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