Helovuo H, Paunio K
Department of Periodontology, University of Turku, Finland.
J Periodontol. 1989 Aug;60(8):467-72. doi: 10.1902/jop.1989.60.8.467.
The clinical effects of systemic penicillin and erythromycin on the periodontium were investigated. There are only a few studies of the effects of these antibiotics on clinical periodontal parameters. Of the 72 subjects in the study, 24 belonged to the penicillin group, 21 to the erythromycin group and 27 to the control group. Plaque and gingival indices, tooth mobility, and probing depths of gingival pockets were recorded before the drug treatment. Radiographs were taken. Both antibiotics decreased plaque, and erythromycin also decreased gingivitis. In the penicillin group 10 of the 24 patients developed abscesses during the study, and the studied clinical parameters worsened. These patients had more severe periodontitis initially than the persons with no acute reaction. The clinical changes had returned to the baseline level by 12 weeks after the antibiotic treatments. There were no significant or lasting effects of antibiotic treatment alone in patients with overt periodontitis.
研究了全身应用青霉素和红霉素对牙周组织的临床效果。关于这些抗生素对临床牙周参数影响的研究较少。该研究中的72名受试者，24名属于青霉素组，21名属于红霉素组，27名属于对照组。在药物治疗前记录菌斑和牙龈指数、牙齿松动度以及牙龈袋探诊深度。拍摄了X光片。两种抗生素均能减少菌斑，红霉素还能减轻牙龈炎。在青霉素组的24名患者中，有10名在研究期间出现脓肿，所研究的临床参数恶化。这些患者最初的牙周炎比无急性反应者更严重。抗生素治疗后12周，临床变化恢复到基线水平。对于明显的牙周炎患者，单独使用抗生素治疗没有显著或持久的效果。
