Helovuo H, Hakkarainen K, Paunio K
Department of Periodontology, Institute of Dentistry, University of Turku, Department of Biomedical Sciences, University of Tampere, Finland.
Oral Microbiol Immunol. 1993 Apr;8(2):75-9. doi: 10.1111/j.1399-302x.1993.tb00548.x.
The changes in the balance of microbial flora in the periodontium after antibiotic treatment were investigated in a blind study. The prevalence of gram-negative enteric rods, staphylococci and yeasts was followed before and during penicillin or erythromycin treatment of 72 periodontitis patients without periodontal cleaning. The prevalence of subgingival coagulase-positive staphylococci increased significantly following systemic penicillin therapy. After systemic erythromycin therapy, the prevalence of subgingival gram-negative enteric rods increased. Ten of 24 (42%) patients receiving systemic penicillin therapy developed clinical evidence of periodontal abscesses. In the absence of conventional mechanical cleaning, systemic administration of penicillin and erythromycin antibiotic to patients with pre-existing periodontitis may lead to periodontal superinfection with opportunistic organisms.
在一项盲法研究中，调查了抗生素治疗后牙周组织中微生物菌群平衡的变化。在对72例未经牙周清洁的牙周炎患者进行青霉素或红霉素治疗之前及治疗期间，对革兰氏阴性肠道杆菌、葡萄球菌和酵母菌的流行情况进行了跟踪。全身应用青霉素治疗后，龈下凝固酶阳性葡萄球菌的流行率显著增加。全身应用红霉素治疗后，龈下革兰氏阴性肠道杆菌的流行率增加。接受全身青霉素治疗的24例患者中有10例（42%）出现了牙周脓肿的临床证据。在没有进行常规机械清洁的情况下，对已有牙周炎的患者全身应用青霉素和红霉素抗生素可能会导致机会性微生物引起的牙周二重感染。
