基于肽开发的下一代纳米抗菌工具。

Next-generation nanoantibacterial tools developed from peptides.

机构信息

2Department of Biomedical Engineering, University Medical Center Groningen, University of Groningen, PO Box 196, 9700 AD Groningen, The Netherlands.

3Departamento de Bioquímica e Programa de Pós-Graduação em Inovação Terapêutica, Universidade Federal de Pernambuco, 50670-901 Recife, PE, Brazil.

出版信息

Nanomedicine (Lond). 2015 May;10(10):1643-61. doi: 10.2217/nnm.15.9.

DOI:10.2217/nnm.15.9

PMID:26008197

Abstract

Bacteria resistant against various antimicrobial compounds have emerged in many countries, and the age of resistance has just started. Among the more promising novel antimicrobial compounds on which current research is focusing are the antimicrobial peptides (AMPs). These are often less susceptible to bacterial resistance since multiple modifications in the cellular membranes, cell wall and metabolism are required to reduce their effectiveness. Most likely, the use of pure AMPs will be insufficient for controlling pathogenic bacteria, and innovative approaches are required to employ AMPs in new antibiotic treatments. Therefore, here we review novel bionanotechnological approaches, including nanofibers, nanoparticles and magnetic particles for effectively using AMPs in fighting infectious diseases.

摘要

在许多国家，已经出现了对抗各种抗菌化合物的细菌，而耐药时代才刚刚开始。目前研究的重点是一些更有前途的新型抗菌化合物，包括抗菌肽 (AMPs)。由于需要对细胞膜、细胞壁和新陈代谢进行多次修饰才能降低其效果，因此这些化合物通常不太容易产生细菌耐药性。很可能，单独使用 AMPs 不足以控制致病菌，因此需要采用创新方法将 AMPs 应用于新型抗生素治疗中。因此，在这里我们综述了新型生物纳米技术方法，包括纳米纤维、纳米颗粒和磁性颗粒，以有效利用 AMPs 来对抗传染病。