BIOlab Research Group, Department of Chemistry & Industrial Chemistry, University of Pisa, UdR INSTM Pisa, Via G. Moruzzi 13, 56124 Pisa, Italy.
Department of Translational Research & New Technology in Medicine & Surgery, University of Pisa, Via S. Zeno 35-39, 56127 Pisa, Italy.
Nanomedicine (Lond). 2016 Jul;11(13):1729-44. doi: 10.2217/nnm-2016-0057. Epub 2016 Jun 27.
Antimicrobial peptides (AMPs) are a class of promising anti-infective molecules but their therapeutic application is opposed by their poor bioavailability, susceptibility to protease degradation and potential toxicity. The advancement of nanoformulation technologies offers encouraging perspectives for the development of novel therapeutic strategies based on AMPs to treat antibiotic resistant microbial infections. Additionally, the use of polymers endowed per-se with antibacterial properties, stands out as an innovative approach for the development of a new generation of drug delivery systems in which an enhanced antimicrobial action could be obtained by the synergic combination of bioactive polymer matrices and drugs. Herein, the latest AMPs drug delivery research is discussed.
抗菌肽 (AMPs) 是一类很有前途的抗感染分子，但由于其生物利用度差、易被蛋白酶降解以及潜在毒性，其治疗应用受到了限制。纳米制剂技术的进步为基于 AMP 开发新型治疗策略以治疗抗生素耐药性微生物感染提供了令人鼓舞的前景。此外，具有抗菌性能的聚合物的使用，为新一代药物输送系统的开发提供了一种创新方法，通过生物活性聚合物基质和药物的协同组合，可以获得增强的抗菌作用。本文讨论了抗菌肽药物输送的最新研究进展。
