Wirostko E, Johnson L, Wirostko W
Edward S. Harkness Eye Institute, Columbia-Presbyterian Medical Center, New York, NY 10032.
J Rheumatol. 1989 Nov;16(11):1446-53.
Patients with juvenile rheumatoid arthritis (JRA) commonly develop serious eye disease, particularly chronic uveitis. Most chronic uveitis is idiopathic. Mollicute-like organisms (MLO) were recently reported to be a common cause of chronic uveitis. MLO are pathogenic intracellular cell wall deficient bacteria. No culture system exists for MLO. Disease diagnosis is based on detection using a transmission electron microscope. Uveitis producing MLO are detectable within parasitized intraocular leukocytes. They appear as intracytoskeletal 0.005-0.01 micron diameter filaments and undulating pleomorphic 0.01-1.0 micron tubulospherical bodies. This report describes MLO parasitized lesional leukocytes in the inflammatory eye disease of 5 patients with JRA. Our results indicate that MLO caused the uveitis of these patients. The significance of these findings and rifampin treatment of MLO disease are discussed.
青少年类风湿性关节炎（JRA）患者通常会患上严重的眼部疾病，尤其是慢性葡萄膜炎。大多数慢性葡萄膜炎是特发性的。最近有报道称，类支原体样微生物（MLO）是慢性葡萄膜炎的常见病因。MLO是致病性细胞内细胞壁缺陷细菌。目前不存在用于培养MLO的系统。疾病诊断基于透射电子显微镜检测。产生葡萄膜炎的MLO可在被寄生的眼内白细胞中检测到。它们表现为直径0.005 - 0.01微米的胞内骨架细丝以及直径0.01 - 1.0微米的波浪状多形性管球状体。本报告描述了5例JRA患者炎性眼病中被MLO寄生的病变白细胞。我们的结果表明，MLO导致了这些患者的葡萄膜炎。文中讨论了这些发现的意义以及利福平对MLO疾病的治疗作用。
