Wirostko E, Johnson L, Wirostko B
Edward S. Harkness Eye Institute, Columbia-Presbyterian Medical Center, New York, NY.
Acta Ophthalmol (Copenh). 1989 Aug;67(4):415-24. doi: 10.1111/j.1755-3768.1989.tb01626.x.
Mollicute-Like Organisms (MLO) have been reported to be a cause of uveal tract and orbital chronic inflammatory disease. MLO are intracellular cytopathogenic cell wall deficient bacteria. No culture system exists for MLO, MLO disease diagnosis is based chiefly on direct detection of the organisms within diseased cells using a transmission electron microscope. Uveitis producing MLO are detectable within vitreous leucocytes as 0.005-0.01 micron filaments and undulating pleomorphic 0.01-1.0 micron tubulo-spherical bodies. Human uveitis producing MLO can be passed to laboratory animals. Inoculation into mouse eyelids produced intraocular, orbital, and lethal systemic chronic progressive inflammatory disease. MLO parasitised lesional leucocytes were found in all the disease sites. The MLO induced mouse chronic interstitial pneumonitis displayed 'sarcoid-like' granulomas. This report describes MLO parasitised vitreous leucocytes in the chronic uveitis of four sarcoidosis patients. The results indicate that MLO caused the uveitis. The implications of the results and Rifampin treatment of MLO disease are discussed.
据报道，类支原体生物（MLO）是葡萄膜和眼眶慢性炎症性疾病的病因之一。MLO是细胞内致病性细胞壁缺陷细菌。目前尚无针对MLO的培养系统，MLO疾病的诊断主要基于使用透射电子显微镜直接检测病变细胞内的病原体。可在玻璃体白细胞内检测到产生葡萄膜炎的MLO，呈0.005 - 0.01微米的细丝状以及0.01 - 1.0微米的波浪状多形性管球形体。人类产生葡萄膜炎的MLO可传染给实验动物。接种到小鼠眼睑可导致眼内、眼眶及致死性全身性慢性进行性炎症性疾病。在所有疾病部位均发现有MLO寄生的病变白细胞。MLO诱导的小鼠慢性间质性肺炎表现为“结节病样”肉芽肿。本报告描述了4例结节病患者慢性葡萄膜炎中MLO寄生的玻璃体白细胞。结果表明MLO导致了葡萄膜炎。并对结果的意义以及利福平治疗MLO疾病进行了讨论。
