小胶质细胞对神经发生的影响。
Effects of Microglia on Neurogenesis.
作者信息
Sato Kaoru
机构信息
Division of Pharmacology, Laboratory of Neuropharmacology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-Ku, Tokyo, 158-8501, Japan.
出版信息
Glia. 2015 Aug;63(8):1394-405. doi: 10.1002/glia.22858. Epub 2015 May 24.
Abstract
This review summarizes and organizes the literature concerning the effects of microglia on neurogenesis, particularly focusing on the subgranular zone (SGZ) of the hippocampus and subventricular zone (SVZ) of the lateral ventricles, in which the neurogenic potential is progressively restricted during the life of the organism. A comparison of microglial roles in neurogenesis in these two regions indicates that microglia regulate neurogenesis in a temporally and spatially specific manner. Microglia may also sense signals from the surrounding environment and have regulatory effects on neurogenesis. We speculate microglia function as a hub for the information obtained from the inner and outer brain regions for regulating neurogenesis.
摘要
本综述总结并梳理了有关小胶质细胞对神经发生影响的文献，特别关注海马体的颗粒下区（SGZ）和侧脑室的室下区（SVZ），在这些区域中，神经发生潜能在生物体生命过程中逐渐受到限制。对这两个区域小胶质细胞在神经发生中作用的比较表明，小胶质细胞以时间和空间特异性的方式调节神经发生。小胶质细胞还可能感知来自周围环境的信号，并对神经发生产生调节作用。我们推测小胶质细胞作为从大脑内部和外部区域获取信息的枢纽，用于调节神经发生。
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