Apoorv Thittayil Suresh, Babu Phanithi Prakash, Meese Stefanie, Gai Prabhanjan P, Bedu-Addo George, Mockenhaupt Frank P
Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, India; Institute of Tropical Medicine and International Health, Charité Universitätsmedizin Berlin, Berlin, Germany; Department of Medicine, Komfo Anoyke Teaching Hospital, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, India; Institute of Tropical Medicine and International Health, Charité Universitätsmedizin Berlin, Berlin, Germany; Department of Medicine, Komfo Anoyke Teaching Hospital, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
Am J Trop Med Hyg. 2015 Jul;93(1):186-8. doi: 10.4269/ajtmh.14-0816. Epub 2015 May 26.
Phagocytosis of malaria pigment (hemozoin) induces increased activity of matrix metalloproteinase (MMP)-9, an endopeptidase involved in cytokine regulation. In this study, we examined whether a common functional MMP-9 promoter polymorphism (rs3918242) affects Plasmodium falciparum infection in pregnancy. Eighteen percent of Ghanaian primiparae carried the minor T allele. It was associated with reduced odds of placental hemozoin and of placental as well as peripheral blood parasitemia. The results indicate that a common MMP-9 polymorphism protects against placental malaria indicating that this endopeptidase is involved in susceptibility to P. falciparum.
疟色素（疟原虫血红素）的吞噬作用会诱导基质金属蛋白酶（MMP）-9（一种参与细胞因子调节的内肽酶）的活性增加。在本研究中，我们检测了一种常见的功能性MMP-9启动子多态性（rs3918242）是否影响妊娠期间的恶性疟原虫感染。18%的加纳初产妇携带次要的T等位基因。它与胎盘疟色素以及胎盘和外周血寄生虫血症的几率降低有关。结果表明，一种常见的MMP-9多态性可预防胎盘疟疾，这表明这种内肽酶与恶性疟原虫易感性有关。
