Universidade Nova de Lisboa, Rua da Junqueira, 96, 1349-008 Lisboa, Portugal.
Trans R Soc Trop Med Hyg. 2010 Oct;104(10):687-9. doi: 10.1016/j.trstmh.2010.05.005. Epub 2010 Jun 30.
Our understanding about the role of the maternal genetic factors on placental malaria is scarce. The general aim of this work was to examine whether common polymorphisms of genes involved in chondroitin sulphate A (CSA) synthesis influence susceptibility to and manifestation of malaria during pregnancy. To achieve this, 96 women with placental malaria and 180 healthy controls without malaria from the province of Luanda, Angola, were genotyped using six microsatellite loci. No associations were found between polymorphisms of genes involved in CSA synthesis and placental malaria. All these findings suggest that there is no genetic susceptibility or increased risk attributed to polymorphisms of the enzymes involved on the synthesis of CSA.
我们对母体遗传因素在胎盘疟疾中的作用的了解还很有限。这项工作的总体目标是研究参与硫酸软骨素 A（CSA）合成的基因的常见多态性是否会影响妊娠期间疟疾的易感性和表现。为此，在安哥拉罗安达省，对 96 名患有胎盘疟疾的妇女和 180 名无疟疾的健康对照者进行了基因分型，使用了 6 个微卫星位点。未发现 CSA 合成相关基因多态性与胎盘疟疾之间存在关联。所有这些发现表明，CSA 合成相关酶的多态性不存在遗传易感性或增加的风险。
