Lee Woo Jin, Won Kwang Hee, Won Chong Hyun, Chang Sung Eun, Choi Jee Ho, Moon Kee Chan, Park Chan-Sik, Huh Jooryung, Suh Cheolwon, Lee Mi Woo
Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Acta Derm Venereol. 2016 Feb;96(2):245-50. doi: 10.2340/00015555-2139.
Diffuse large B-cell lymphoma (DLBCL) can be separated into 2 groups: nodal and extranodal disease. The aim of this study was to analyse the clinical features of skin lesions and survival outcomes of cutaneous DLBCL according to the primary tumour site. A total of 44 patients with cutaneous DLBCL were classified as primary cutaneous DLBCL, leg type or cutaneous DLBCL secondary to primary disease. Although skin lesion characteristics did not differ significantly between groups, extensive cutaneous lesions were more often observed in secondary cutaneous DLBCL compared with DLBCL, leg type. Secondary cutaneous DLBCL was more commonly associated with an advanced stage and higher International Prognostic Index score than DLBCL, leg type. DLBCL, leg type demonstrated a better survival outcome than secondary cutaneous DLBCL. The multiplicity of skin lesions and time-point of cutaneous involvement were associated with prognosis in secondary cutaneous DLBCL. Survival outcomes and prognostic factors differ depending on the primary tumour site of cutaneous DLBCL.
弥漫性大B细胞淋巴瘤（DLBCL）可分为两组：淋巴结疾病和结外疾病。本研究的目的是根据原发性肿瘤部位分析皮肤DLBCL皮肤病变的临床特征和生存结果。共有44例皮肤DLBCL患者被分类为原发性皮肤DLBCL、腿部型或原发性疾病继发的皮肤DLBCL。尽管各组之间的皮肤病变特征没有显著差异，但与腿部型DLBCL相比，继发性皮肤DLBCL中更常观察到广泛的皮肤病变。继发性皮肤DLBCL比腿部型DLBCL更常与晚期和更高的国际预后指数评分相关。腿部型DLBCL的生存结果优于继发性皮肤DLBCL。皮肤病变的多样性和皮肤受累的时间点与继发性皮肤DLBCL的预后相关。皮肤DLBCL的生存结果和预后因素因原发性肿瘤部位而异。
