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老年女性髋部骨折后的死亡率趋势。

Trends in mortality following hip fracture in older women.

作者信息

Lo Joan C, Srinivasan Sowmya, Chandra Malini, Patton Mary, Budayr Amer, Liu Lucy H, Lau Gene, Grimsrud Christopher D

出版信息

Am J Manag Care. 2015 Mar 1;21(3):e206-14.

Abstract

OBJECTIVES

To examine contemporary trends in mortality following hip fracture among older postmenopausal women in an integrated healthcare delivery system.

STUDY DESIGN

Retrospective cohort study of 13,550 women aged ≥65 years with hip fracture during 2000 to 2010.

METHODS

Demographic factors, comorbidity index score, fracture history, early rehospitalization, and all-cause mortality within 1 year following hip fracture were examined using health plan databases and records. Temporal trends, risk factors, and the association of race/ethnicity and mortality within 1 year post fracture were examined using multivariable logistic regression.

RESULTS

Among 13,550 women with hip fracture, 84.6% were aged ≥75 years: 83.6% were white, 2.8% black, 5.6% Hispanic, 4.5% Asian, and 3.5% of other/unknown race. Following hip fracture, 2.4% died during the index hospitalization, while 12.3% were rehospitalized within 30 days of discharge. Infection, pneumonia, and cardiovascular conditions were the most common nonorthopedic indications for readmission. Mortality rates at 6 months (17%) and 1 year (22.8%) following hip fracture were high and increased with age. Greater comorbidity and early rehospitalization were associated with increased mortality risk, while Asian and Hispanic race/ethnicity were associated with lower mortality risk (vs white). Temporal trends demonstrated a small but significant reduction in mortality risk during 2004 to 2010.

CONCLUSIONS

While hip fracture morbidity and mortality remain high, temporal trends suggest recent declines in mortality risk, with risk of death following hip fracture lower for Asian and Hispanic women. Future studies should examine potential benefits of targeted interventions within integrated healthcare settings and factors contributing to observed racial/ethnic differences in post fracture survival.

摘要

目的

在一个综合医疗服务体系中,研究老年绝经后女性髋部骨折后的当代死亡率趋势。

研究设计

对2000年至2010年间13550名年龄≥65岁的髋部骨折女性进行回顾性队列研究。

方法

使用健康计划数据库和记录,检查人口统计学因素、合并症指数评分、骨折史、早期再入院情况以及髋部骨折后1年内的全因死亡率。使用多变量逻辑回归分析时间趋势、风险因素以及骨折后1年内种族/族裔与死亡率的关联。

结果

在13550名髋部骨折女性中,84.6%年龄≥75岁:83.6%为白人,2.8%为黑人,5.6%为西班牙裔,4.5%为亚洲人,3.5%为其他/种族不明。髋部骨折后,2.4%在首次住院期间死亡,而12.3%在出院后30天内再次入院。感染、肺炎和心血管疾病是再次入院最常见的非骨科指征。髋部骨折后6个月(17%)和1年(22.8%)的死亡率较高,且随年龄增加。合并症增加和早期再入院与死亡风险增加相关,而亚洲和西班牙裔种族/族裔与较低的死亡风险相关(与白人相比)。时间趋势表明,2004年至2010年间死亡风险有小幅但显著的降低。

结论

虽然髋部骨折的发病率和死亡率仍然很高,但时间趋势表明近期死亡风险有所下降,亚洲和西班牙裔女性髋部骨折后的死亡风险较低。未来的研究应探讨在综合医疗环境中进行有针对性干预的潜在益处,以及导致观察到的骨折后生存种族/族裔差异的因素。

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