Cui Yun-Pu, Zhang Ming-Tao, Wang Xin-Li
Department of Pediatrics, Peking University Third Hospital, Beijing 100191, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2015 May;17(5):464-8.
To study the characteristics of R bone age, C bone age, and T bone age in children with different causes of short stature based on the Tanner and Whitehouse skeletal age assessment system 2 (TW2), and to provide a reference for the etiological diagnosis of short stature.
Three hundred and sixty-three children with previously untreated short stature were classified into four groups according to the causes: growth hormone deficiency (GHD; 27 cases), idiopathic short stature (ISS; 280 cases), small for gestational age (SGA; 41 cases), and Turner syndrome (TS; 15 cases). The X-ray films of their left hand-wrist bones were taken to determine the bone age. R bone age, C bone age, and T bone age were assessed by the TW2 method and compared with their chronological age (CA).
R bone age, C bone age, and T bone age were over 2 years less than CA in both boys and girls from the GHD group. In the ISS group, R bone age, C bone age, and T bone age were about 1 year less than CA in boys, while there were no significant differences between the bone ages and CA in girls. In the SGA group, there were no significant differences between the bone ages and CA in either boys or girls. In the TS group, R bone age and T bone age were significantly lower than CA, while there was no significant difference between C bone age and CA.
The children with different causes of short stature have different characteristics of R bone age, C bone age, and T bone age assessed by the TW2 method. The assessment of R bone age, C bone age, and T bone age by the TW2 method is helpful for the etiological diagnosis of short stature in children.
基于坦纳和怀特豪斯骨骼发育年龄评估系统2（TW2），研究不同病因导致身材矮小儿童的R骨龄、C骨龄和T骨龄特征，为身材矮小的病因诊断提供参考。
将363例未经治疗的身材矮小儿童按病因分为四组：生长激素缺乏症（GHD；27例）、特发性身材矮小（ISS；280例）、小于胎龄儿（SGA；41例）和特纳综合征（TS；15例）。拍摄其左手腕部X线片以确定骨龄。采用TW2法评估R骨龄、C骨龄和T骨龄，并与实际年龄（CA）进行比较。
GHD组男孩和女孩的R骨龄、C骨龄和T骨龄均比CA小2岁以上。ISS组男孩的R骨龄、C骨龄和T骨龄比CA小约1岁，而女孩的骨龄与CA之间无显著差异。SGA组男孩和女孩的骨龄与CA之间均无显著差异。TS组R骨龄和T骨龄显著低于CA，而C骨龄与CA之间无显著差异。
不同病因导致身材矮小的儿童，采用TW2法评估的R骨龄、C骨龄和T骨龄具有不同特征。采用TW2法评估R骨龄、C骨龄和T骨龄有助于儿童身材矮小的病因诊断。
