中国首次报告产 OXA-181 型大肠埃希菌及应用全基因组测序对分离株进行的特征分析。
First Report of OXA-181-Producing Escherichia coli in China and Characterization of the Isolate Using Whole-Genome Sequencing.
机构信息
Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China Division of Infectious Diseases, State Key Laboratory of Biotherapy, Chengdu, China.
Laboratory of Clinical Microbiology, Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
出版信息
Antimicrob Agents Chemother. 2015 Aug;59(8):5022-5. doi: 10.1128/AAC.00442-15. Epub 2015 May 26.
Abstract
We report the first OXA-181-producing strain in China. blaOXA-181 was found in sequence type 410 (ST410) Escherichia coli strain WCHEC14828 from a Chinese patient without recent travel history. Genome sequencing and conjugation experiments were performed. blaOXA-181 was carried on a 51-kb self-transmissible IncX3 plasmid and was linked with qnrS1, a quinolone resistance gene. blaOXA-181 was introduced onto the IncX3 plasmid from a ColE2-type plasmid, and IncX3 plasmids have the potential to mediate the dissemination of blaOXA-181.
摘要
我们报告了中国首例产 OXA-181 菌株。blaOXA-181 存在于一位无近期旅行史的中国患者携带的序列型 410（ST410）大肠埃希菌 WCHEC14828 中。进行了基因组测序和接合实验。blaOXA-181 位于一个 51kb 的可自我传播的 IncX3 质粒上，与喹诺酮类耐药基因 qnrS1 相连。blaOXA-181 由 ColE2 型质粒引入 IncX3 质粒，而 IncX3 质粒有可能介导 blaOXA-181 的传播。
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