来自中国一株流行的大肠杆菌序列型131菌株的产KPC的IncN多药耐药质粒的完整序列。
Complete sequence of a KPC-producing IncN multidrug-resistant plasmid from an epidemic Escherichia coli sequence type 131 strain in China.
作者信息
Chen Liang, Hu Hongyan, Chavda Kalyan D, Zhao Shulong, Liu Renkun, Liang Hui, Zhang Wei, Wang Xiumei, Jacobs Michael R, Bonomo Robert A, Kreiswirth Barry N
机构信息
Public Health Research Institute TB Center, NJMS-Rutgers University, Newark, New Jersey, USA.
出版信息
Antimicrob Agents Chemother. 2014;58(4):2422-5. doi: 10.1128/AAC.02587-13. Epub 2014 Jan 6.
Abstract
We report here the nucleotide sequence of a novel blaKPC-2-harboring incompatibility group N (IncN) plasmid, pECN580, from a multidrug-resistant Escherichia coli sequence type 131 (ST131) isolate recovered from Beijing, China. pECN580 harbors β-lactam resistance genes blaKPC-2, blaCTX-M-3, and blaTEM-1; aminoglycoside acetyltransferase gene aac(6')-Ib-cr; quinolone resistance gene qnrS1; rifampin resistance gene arr-3; and trimethoprim resistance gene dfrA14. The emergence of a blaKPC-2-harboring multidrug-resistant plasmid in an epidemic E. coli ST131 clone poses a significant potential threat in community and hospital settings.
摘要
我们在此报告从中国北京分离出的一株多重耐药性大肠杆菌序列型131（ST131）中，一个携带新型blaKPC - 2的不相容群N（IncN）质粒pECN580的核苷酸序列。pECN580含有β - 内酰胺抗性基因blaKPC - 2、blaCTX - M - 3和blaTEM - 1；氨基糖苷乙酰转移酶基因aac(6') - Ib - cr；喹诺酮抗性基因qnrS1；利福平抗性基因arr - 3；以及甲氧苄啶抗性基因dfrA14。在流行的大肠杆菌ST131克隆中出现携带blaKPC - 2的多重耐药性质粒，在社区和医院环境中构成了重大潜在威胁。
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