两性霉素 B 联合泊沙康唑对实验性播散性孢子丝菌病的体外和体内疗效。
In Vitro and In Vivo Efficacy of Amphotericin B Combined with Posaconazole against Experimental Disseminated Sporotrichosis.
机构信息
Microbiology Unit, Medical School, Universitat Rovira i Virgili, IISPV, Reus, Spain.
Department of Microbiology and Parasitology, Universidade Federal de Santa Maria, Santa Maria, Brazil.
出版信息
Antimicrob Agents Chemother. 2015 Aug;59(8):5018-21. doi: 10.1128/AAC.00052-15. Epub 2015 May 26.
Abstract
We evaluated the combination of posaconazole with amphotericin B in vitro and in a murine model of systemic infections caused by Sporothrix brasiliensis and Sporothrix schenckii sensu stricto. In vitro data demonstrated a synergistic effect, and although posaconazole alone was effective against sporotrichosis, efficacy in terms of survival and burden reduction was increased with the combination. This combination might be an option against disseminated sporotrichosis, especially when itraconazole or amphotericin B at optimal doses are contraindicated.
摘要
我们评估了泊沙康唑与两性霉素 B 在体外和巴西副球孢子菌和申克孢子丝菌（严格意义上的）引起的系统性感染的小鼠模型中的联合作用。体外数据显示出协同作用，尽管泊沙康唑单独对孢子丝菌病有效，但联合用药可提高存活率和降低负担方面的疗效。这种联合用药可能是治疗播散性孢子丝菌病的一种选择，尤其是当最佳剂量的伊曲康唑或两性霉素 B 禁忌时。
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