心叶青牛胆乙醇提取物对N-亚硝基二乙胺诱导的雄性Wistar白化大鼠肝癌的抗氧化活性。
Antioxidant activity of ethanolic extract of Tinospora cordifolia on N-nitrosodiethylamine (diethylnitrosamine) induced liver cancer in male Wister albino rats.
作者信息
Jayaprakash R, Ramesh V, Sridhar M P, Sasikala C
机构信息
Department of Pharmacology, Dr. A. L. M. P. G. Institute of Basic Medical Sciences, Chennai, Tamil Nadu, India.
Department of Biochemistry, Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry, Affiliated to Bharath University, Chennai, Tamil Nadu, India.
出版信息
J Pharm Bioallied Sci. 2015 Apr;7(Suppl 1):S40-5. doi: 10.4103/0975-7406.155791.
BACKGROUND
Cancer is a disease that evokes wide spread fear among people and is one of the leading causes of deaths in the world. Diethylnitrosamine (DEN) is a known carcinogen in rodent liver. DENs reported to undergo metabolic activation by cytochrome P450 enzymes to form reactive electrophiles that cause oxidative stress leading to cytotoxicity, mutagenicity and carcinogenicity.
OBJECTIVE
The present study was carried out to evaluate the antioxidant activity of ethanolic extract of Tinospora cordifolia (EETC) in N-nitrosodiethylamine (DEN) induced liver cancer in male Wister albino rats.
MATERIALS AND METHODS
The antioxidant activity was assessed by the levels of lipid peroxidation (LPO), enzymic and nonenzymic antioxidants.
RESULT
A significant levels of LPO was increased as the enzymic and nonenzymic antioxidants values were decreased in liver cancer bearing animals.
CONCLUSIONS
The administration of EETC to cancer bearing animals reverted the LPO levels, enzymic and nonenzymic antioxidants to near normal.
背景
癌症是一种引发人们广泛恐惧的疾病，是全球主要死因之一。二乙基亚硝胺（DEN）是一种已知的啮齿动物肝脏致癌物。据报道，DEN经细胞色素P450酶代谢活化形成反应性亲电试剂，导致氧化应激，进而引起细胞毒性、致突变性和致癌性。
目的
本研究旨在评估心叶青牛胆乙醇提取物（EETC）对N-亚硝基二乙胺（DEN）诱导的雄性Wistar白化大鼠肝癌的抗氧化活性。
材料与方法
通过脂质过氧化（LPO）水平、酶促和非酶促抗氧化剂来评估抗氧化活性。
结果
患肝癌动物的LPO水平显著升高，同时酶促和非酶促抗氧化剂值降低。
结论
给患癌动物施用EETC可使LPO水平、酶促和非酶促抗氧化剂恢复至接近正常水平。
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