Panneerselvam Dhaya Shankaran, Kanakaraja Abinaya, Sakthivelu Meenakumari, Gopinath Subash C B, Raman Pachaiappan
Department of Biotechnology, School of Bioengineering, College of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, 603203, Tamil Nadu, India.
Faculty of Chemical Engineering & Technology, Universiti Malaysia Perlis, Arau 02600, Perlis, Malaysia.
Curr Med Chem. 2025;32(10):1887-1933. doi: 10.2174/0109298673272435231204072922.
Neurodegenerative diseases (NDDs) comprise a large number of disorders that affects the structure and functions of the nervous system. The major cause of various neurodegenerative diseases includes protein aggregation, oxidative stress and inflammation. Over the last decade, there has been a gradual inclination in neurological research in order to find drugs that can prevent, slow down, or treat these diseases. The most common NDDs are Alzheimer's, Parkinson's, and Huntington's illnesses, which claims the lives of 6.8 million people worldwide each year and it is expected to rise by 7.1%. The focus on alternative medicine, particularly plant-based products, has grown significantly in recent years. Plants are considered as a good source of biologically active molecules and hence phytochemical screening of plants will pave way for the discovering new drugs. Neurodegeneration has been linked to oxidative stress, either as a direct cause or as a side effect of other variables. Therefore, it has been proposed that the use of antioxidants to combat cellular oxidative stress within the nervous system may be a viable therapeutic strategy for neurological illnesses. In order to prevent and treat NDDs, this review article covers the therapeutic compounds/ metabolites from plants with the neuroprotective role. However, these exhibit other beneficial molecular functions in addition to antioxidative activity, making them a potential application in the management or prevention of neurodegenerative disorders. Further, it gives the insights to the future researchers about considering the peptide based therapeutics through various mechanisms for delaying or curing neurodegenerative diseases.
神经退行性疾病（NDDs）包括大量影响神经系统结构和功能的疾病。各种神经退行性疾病的主要病因包括蛋白质聚集、氧化应激和炎症。在过去十年中，神经学研究逐渐倾向于寻找能够预防、减缓或治疗这些疾病的药物。最常见的神经退行性疾病是阿尔茨海默病、帕金森病和亨廷顿病，这些疾病每年在全球导致680万人死亡，预计还将上升7.1%。近年来，对替代医学，特别是植物源产品的关注显著增加。植物被认为是生物活性分子的良好来源，因此对植物进行植物化学筛选将为发现新药铺平道路。神经退行性变与氧化应激有关，无论是作为直接原因还是其他变量的副作用。因此，有人提出使用抗氧化剂来对抗神经系统内的细胞氧化应激可能是治疗神经疾病的一种可行策略。为了预防和治疗神经退行性疾病，这篇综述文章涵盖了具有神经保护作用的植物治疗化合物/代谢物。然而，这些化合物除了具有抗氧化活性外，还表现出其他有益的分子功能，使其在神经退行性疾病的管理或预防中具有潜在应用价值。此外，它还为未来的研究人员提供了关于通过各种机制考虑基于肽的疗法来延缓或治愈神经退行性疾病的见解。
