一锅法四组分合成高取代的[1,2,4]三唑并[1,5-a]嘧啶
One-pot four-component synthesis of highly substituted [1,2,4]triazolo[1,5-a]pyrimidines.
作者信息
Shaabani Ahmad, Seyyedhamzeh Mozhdeh, Ganji Nasim, Hamidzad Sangachin Mona, Armaghan Mahsa
机构信息
Faculty of Chemistry, Shahid Beheshti University, G. C, P. O. Box 19396-4716, Tehran, Iran.
Institute of Materials Research and Engineering, Agency for Science, Technology and Research, 3 Research Link, Singapore, 117602, Singapore.
出版信息
Mol Divers. 2015 Nov;19(4):709-15. doi: 10.1007/s11030-015-9604-4. Epub 2015 May 28.
A green one-pot four-component strategy has been developed for the synthesis of [1,2,4]triazolo[1,5-a]pyrimidine-6-carboxamide derivatives using an amine, 2,2,6-trimethyl-4H-1,3-dioxin-4-one, an aldehyde, and 3-amino-1,2,4-triazole in the presence of a catalytic amount of p-toluenesulfonic acid in water within 4-6 h.
已开发出一种绿色的一锅四组分策略，用于在水相中、催化量的对甲苯磺酸存在下，使用胺、2,2,6-三甲基-4H-1,3-二恶英-4-酮、醛和3-氨基-1,2,4-三唑，在4至6小时内合成[1,2,4]三唑并[1,5-a]嘧啶-6-甲酰胺衍生物。
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