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人类白血病相关致癌基因BCR/ABL的5'非编码区是体外翻译的强效抑制剂。

The 5' noncoding region of the human leukemia-associated oncogene BCR/ABL is a potent inhibitor of in vitro translation.

作者信息

Muller A J, Witte O N

机构信息

Molecular-Biology Institute, University of California, Los Angeles 90024.

出版信息

Mol Cell Biol. 1989 Nov;9(11):5234-8. doi: 10.1128/mcb.9.11.5234-5238.1989.

DOI:10.1128/mcb.9.11.5234-5238.1989
PMID:2601719
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC363679/
Abstract

The mRNA encoding the chimeric BCR/ABL oncogene, which is transcribed from the Philadelphia chromosome in human chronic myelogenous leukemia, has a 5' noncoding sequence greater than 500 bases in length which is highly GC rich and contains a short open reading frame. This untranslated sequence has a dramatic inhibitory effect upon translational efficiency in vitro. However, when BCR/ABL message is expressed in certain cell types such as the NIH 3T3 cell line, the 5' noncoding region has little inhibitory effect on translational efficiency.

摘要

编码嵌合BCR/ABL癌基因的信使核糖核酸（mRNA），它由人类慢性粒细胞白血病的费城染色体转录而来，其5'非编码序列长度超过500个碱基，富含鸟嘌呤和胞嘧啶（GC），并包含一个短的开放阅读框。这个非翻译序列在体外对翻译效率有显著的抑制作用。然而，当BCR/ABL信使核糖核酸在某些细胞类型如NIH 3T3细胞系中表达时，5'非编码区对翻译效率几乎没有抑制作用。

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Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes.点突变确定了AUG起始密码子侧翼的一个序列，该序列可调节真核生物核糖体的翻译。
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