Frediani Fabio, Bussone Gennaro
Neurological and Stroke Unit Division, Headache Center, S. Carlo Borromeo Hospital, Via Pio II 3, 20153, Milan, Italy,
Neurol Sci. 2015 May;36 Suppl 1:71-4. doi: 10.1007/s10072-015-2194-1.
HaNDL (transient headache and neurological deficits with cerebrospinal fluid lymphocytosis) syndrome is an infrequent condition included at group 7 "headache attributed to non-vascular intracranial disorder" in the recent International Classification of Headache Disorders (ICHD-3), code 7.3.5. The description states "migraine-like headache episodes (typically 1-12) accompanied by neurological deficits including hemiparaesthesia, hemiparesis and/or dysphasia, but positive visual symptoms only uncommonly, lasting several hours. There is lymphocytic pleocytosis. The disorder resolves spontaneously within 3 months". In this description confusional state is not considered as a main symptom, even if in the literature this aspect is frequently reported. Here, we report the cases of two young boys presenting with confusional state as the main complaint. The possible pathogenesis of the different clinical presentation is discussed.
哈恩德尔（伴有脑脊液淋巴细胞增多的短暂性头痛和神经功能缺损）综合征是一种罕见病症，被纳入最新版《国际头痛疾病分类》（ICHD - 3）中第7组“归因于非血管性颅内疾病的头痛”，编码为7.3.5。其描述为“类似偏头痛的头痛发作（通常为1 - 12次），伴有包括偏身感觉异常、偏瘫和/或言语困难等神经功能缺损，但仅有视觉症状阳性的情况较为罕见，持续数小时。存在淋巴细胞增多。该病症在3个月内可自发缓解”。在这一描述中，意识模糊状态未被视为主要症状，即便在文献中这一方面经常被报道。在此，我们报告两例以意识模糊状态为主诉的年轻男孩病例。并对不同临床表现的可能发病机制进行了讨论。
