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1
Syndrome of transient Headache and Neurological Deficits with cerebrospinal fluid Lymphocytosis (HaNDL).伴有脑脊液淋巴细胞增多的短暂性头痛和神经功能缺损综合征（HaNDL）
BMJ Case Rep. 2011 Mar 29;2011:bcr0320102862. doi: 10.1136/bcr.03.2010.2862.
2
To handle the HaNDL syndrome through a case: The syndrome of headache with neurologic deficits and cerebrospinal fluid lymphocytosis.通过一个病例来诊治短暂性偏侧神经精神症状伴淋巴细胞增多症（HaNDL）综合征：伴有神经功能缺损和脑脊液淋巴细胞增多的头痛综合征。
Ideggyogy Sz. 2020 Mar 30;73(3-4):135-139. doi: 10.18071/isz.73.0135.
3
An adolescent with pseudomigraine, transient headache, neurological deficits, and lymphocytic pleocytosis (HaNDL Syndrome): case report and review of the literature.一名患有偏头痛样症状、短暂性头痛、神经功能缺损和淋巴细胞增多症（HaNDL综合征）的青少年：病例报告及文献综述
Clin Pediatr (Phila). 2013 Jun;52(6):496-502. doi: 10.1177/0009922813483358. Epub 2013 Apr 3.
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HaNDL syndrome: transient headache and neurological deficits with cerebrospinal fluid lymphocytosis.偏瘫型偏头痛综合征：伴有脑脊液淋巴细胞增多的短暂性头痛和神经功能缺损。
N Z Med J. 2017 Jan 27;130(1449):67-69.
5
[Syndrome of headache, transitory neurological deficits and lymphocytosis in the cerebrospinal fluid].[头痛、短暂性神经功能缺损及脑脊液淋巴细胞增多综合征]
Ugeskr Laeger. 2000 Jan 10;162(2):186-8.
6
[The syndrome of transient headache and neurologic deficits with cerebrospinal fluid lymphocytosis (HaNDL)].[伴有脑脊液淋巴细胞增多的短暂性头痛和神经功能缺损综合征（HaNDL）]
Lakartidningen. 2018 Feb 26;115:EWPH.
7
HaNDL Syndrome: The Innocent Lymphocytic Pleocytosis.HaNDL 综合征：淋巴细胞轻度增多而无明显临床症状。
Neurologist. 2024 May 1;29(3):163-165. doi: 10.1097/NRL.0000000000000546.
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Syndrome of transient headache and neurologic deficits with cerebrospinal fluid lymphocytosis presenting as acute neurological emergencies.以急性神经急症形式出现的伴有脑脊液淋巴细胞增多的短暂性头痛和神经功能缺损综合征。
Cephalalgia. 2017 Mar;37(3):284-289. doi: 10.1177/0333102416642733. Epub 2016 Sep 29.
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Syndrome of transient headache and neurological deficits with cerebrospinal fluid lymphocytosis (HaNDL): A case report with serial electroencephalography (EEG) recordings.. Is there an association with human herpes virus type 7 (HHV-7) infection?伴有脑脊液淋巴细胞增多的短暂性头痛和神经功能缺损综合征（HaNDL）：一例连续脑电图（EEG）记录的病例报告。它与人类疱疹病毒7型（HHV-7）感染有关联吗？
Cephalalgia. 2016 Nov;36(13):1296-1301. doi: 10.1177/0333102415618616. Epub 2016 Jul 20.
10
[HaNDL is transient headache, neurological deficits and lymphocytic pleocytosis in the cerebrospinal fluid].[HaNDL是短暂性头痛、神经功能缺损以及脑脊液淋巴细胞增多症]
Ugeskr Laeger. 2019 Oct 21;181(43).

引用本文的文献

1
HaNDL syndrome in a 14-year-old girl.一名14岁女孩的偏瘫性偏头痛样发作性神经系统障碍综合征
BMJ Case Rep. 2016 Jan 14;2016:bcr2015213018. doi: 10.1136/bcr-2015-213018.
2
Confusional state as first symptom of HaNDL syndrome.意识模糊状态作为短暂性局灶性神经症状伴淋巴细胞增多综合征（HaNDL综合征）的首发症状
Neurol Sci. 2015 May;36 Suppl 1:71-4. doi: 10.1007/s10072-015-2194-1.

本文引用的文献

1
Abnormal MRI in a patient with 'headache with neurological deficits and CSF lymphocytosis (HaNDL)'.MRI 异常的患者，伴有“头痛伴神经功能缺损和 CSF 淋巴细胞增多症（HaNDL）”。
Cephalalgia. 2010 May;30(5):615-9. doi: 10.1111/j.1468-2982.2009.01950.x. Epub 2010 Feb 22.
2
Global hemispheric CT hypoperfusion may differentiate headache with associated neurological deficits and lymphocytosis from acute stroke.全脑半球CT灌注不足可将伴有相关神经功能缺损和淋巴细胞增多的头痛与急性卒中区分开来。
Stroke. 2008 Feb;39(2):492-3. doi: 10.1161/STROKEAHA.107.493791. Epub 2008 Jan 3.
3
[Pseudomigraine with cerebrospinal fluid pleocytosis or syndrome of headache, temporary neurological deficit and cerebrospinal fluid. A historical review].
Rev Neurol. 2007;45(10):624-30.
4
Headache with neurological deficits and CSF lymphocytosis: A transient ischemic attack mimic.伴有神经功能缺损和脑脊液淋巴细胞增多的头痛：一种短暂性脑缺血发作的模仿症状。
J Stroke Cerebrovasc Dis. 1999 Jan-Feb;8(1):42-4. doi: 10.1016/s1052-3057(99)80039-1.
5
The transient syndrome of headache with neurological deficits, cerebrospinal fluid pleocytosis and acute confusional state: a case report.伴有神经功能缺损、脑脊液淋巴细胞增多症及急性意识模糊状态的短暂性头痛综合征：一例报告
J Headache Pain. 2005 Dec;6(6):476. doi: 10.1007/s10194-005-0257-z.
6
Ophthalmologic manifestations in headache, neurologic deficits, and cerebrospinal fluid lymphocytosis (HaNDL) syndrome with nonspecific frontal lesions and hyperthyroidism.
Eye (Lond). 2006 May;20(5):613-5. doi: 10.1038/sj.eye.6701937.
7
[Cytomegalovirus infection mimicking a pseudomigraine with pleocytosis].
An Med Interna. 2004 Jul;21(7):360-1. doi: 10.4321/s0212-71992004000700011.
8
The International Classification of Headache Disorders: 2nd edition.《国际头痛疾病分类：第二版》
Cephalalgia. 2004;24 Suppl 1:9-160. doi: 10.1111/j.1468-2982.2003.00824.x.
9
[A young woman with pseudomigraine with CSF pleocytosis].
Rinsho Shinkeigaku. 2003 Jan-Feb;43(1-2):12-5.
10
Pseudomigraine with lymphocytic pleocytosis.伴有淋巴细胞增多的偏头痛样综合征
Curr Pain Headache Rep. 2003 Jun;7(3):224-8. doi: 10.1007/s11916-003-0077-2.

伴有脑脊液淋巴细胞增多的短暂性头痛和神经功能缺损综合征（HaNDL）

Syndrome of transient Headache and Neurological Deficits with cerebrospinal fluid Lymphocytosis (HaNDL).

作者信息

Cifelli A, Vaithianathar L

机构信息

Department of Neurology, Queen's Hospital, Romford, Essex, UK.

出版信息

BMJ Case Rep. 2011 Mar 29;2011:bcr0320102862. doi: 10.1136/bcr.03.2010.2862.

DOI:10.1136/bcr.03.2010.2862
PMID:22700346
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3070335/
Abstract

A lady in her late 20s was admitted with a history of headaches and intermittent focal neurological symptoms which were greatly exacerbated by catheter angiography of the cerebral circulation. Cerebrospinal fluid analysis demonstrated a lymphocytic pleocytosis. She subsequently made a spontaneous recovery, without neurological sequelae. Her presentation fits the diagnostic criteria for the previously described syndrome of transient headache and neurological deficits with cerebrospinal fluid lymphocytosis (HaNDL). HaNDL is a probably underdiagnosed nosological entity, characterised by often dramatic clinical manifestations but ultimately a good prognosis.

摘要

一位快30岁的女性因头痛病史和间歇性局灶性神经症状入院，这些症状在进行脑循环导管血管造影时显著加重。脑脊液分析显示淋巴细胞增多。她随后自行康复，无神经后遗症。她的表现符合先前描述的伴有脑脊液淋巴细胞增多的短暂性头痛和神经功能缺损综合征（HaNDL）的诊断标准。HaNDL可能是一种诊断不足的疾病实体，其特点是临床表现往往较为显著，但最终预后良好。