伴有脑脊液淋巴细胞增多的短暂性头痛和神经功能缺损综合征（HaNDL）
Syndrome of transient Headache and Neurological Deficits with cerebrospinal fluid Lymphocytosis (HaNDL).
作者信息
Cifelli A, Vaithianathar L
机构信息
Department of Neurology, Queen's Hospital, Romford, Essex, UK.
出版信息
BMJ Case Rep. 2011 Mar 29;2011:bcr0320102862. doi: 10.1136/bcr.03.2010.2862.
Abstract
A lady in her late 20s was admitted with a history of headaches and intermittent focal neurological symptoms which were greatly exacerbated by catheter angiography of the cerebral circulation. Cerebrospinal fluid analysis demonstrated a lymphocytic pleocytosis. She subsequently made a spontaneous recovery, without neurological sequelae. Her presentation fits the diagnostic criteria for the previously described syndrome of transient headache and neurological deficits with cerebrospinal fluid lymphocytosis (HaNDL). HaNDL is a probably underdiagnosed nosological entity, characterised by often dramatic clinical manifestations but ultimately a good prognosis.
摘要
一位快30岁的女性因头痛病史和间歇性局灶性神经症状入院，这些症状在进行脑循环导管血管造影时显著加重。脑脊液分析显示淋巴细胞增多。她随后自行康复，无神经后遗症。她的表现符合先前描述的伴有脑脊液淋巴细胞增多的短暂性头痛和神经功能缺损综合征（HaNDL）的诊断标准。HaNDL可能是一种诊断不足的疾病实体，其特点是临床表现往往较为显著，但最终预后良好。
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本文引用的文献
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Cephalalgia. 2010 May;30(5):615-9. doi: 10.1111/j.1468-2982.2009.01950.x. Epub 2010 Feb 22.
2
Global hemispheric CT hypoperfusion may differentiate headache with associated neurological deficits and lymphocytosis from acute stroke.全脑半球CT灌注不足可将伴有相关神经功能缺损和淋巴细胞增多的头痛与急性卒中区分开来。
Stroke. 2008 Feb;39(2):492-3. doi: 10.1161/STROKEAHA.107.493791. Epub 2008 Jan 3.
3
4
Headache with neurological deficits and CSF lymphocytosis: A transient ischemic attack mimic.伴有神经功能缺损和脑脊液淋巴细胞增多的头痛：一种短暂性脑缺血发作的模仿症状。
J Stroke Cerebrovasc Dis. 1999 Jan-Feb;8(1):42-4. doi: 10.1016/s1052-3057(99)80039-1.
5
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J Headache Pain. 2005 Dec;6(6):476. doi: 10.1007/s10194-005-0257-z.
6
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Eye (Lond). 2006 May;20(5):613-5. doi: 10.1038/sj.eye.6701937.
7
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8
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10
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