Clemens M R, Bursa-Zanetti Z
Medizinische Klinik und Poliklinik, Eberhard-Karls-Universität, Tubingen, FRG.
Nephron. 1989;53(4):325-9. doi: 10.1159/000185776.
Serum lipid abnormalities are a common feature of the nephrotic syndrome. It is suggested that this may influence the membrane lipid composition of red cells, which on the other hand may result in an abnormal sensitivity of red cells to lipid peroxidation. Therefore, lipids of plasma and red cell membranes from 7 patients with nephrotic syndrome and from 31 healthy control subjects were examined. In addition, the consequences for the hydrogen-peroxide-induced lipid peroxidation of red cells as an index for their capacity to compensate for oxidant stress was measured. All patients were anemic. Their red cells exhibited a significantly increased susceptibility to lipid peroxidation. Fatty acid analysis revealed a decreased proportion of linoleic acid in plasma and red cell membrane. The content of cholesterol in patients' red cell membranes was clearly diminished. It is shown that this abnormality was related to the enhanced sensitivity of their red cells for peroxidative stress. The present study shows that in addition to an impairment of red cells' antioxidant enzymes, abnormalities of the membrane lipid composition should be considered investigating the cause for an increased susceptibility to lipid peroxidation.
血清脂质异常是肾病综合征的常见特征。有人认为，这可能会影响红细胞的膜脂质组成，而这反过来可能导致红细胞对脂质过氧化的异常敏感性。因此，对7例肾病综合征患者和31例健康对照者的血浆和红细胞膜脂质进行了检测。此外，还测定了过氧化氢诱导的红细胞脂质过氧化的后果，以此作为其补偿氧化应激能力的指标。所有患者均贫血。他们的红细胞对脂质过氧化的敏感性显著增加。脂肪酸分析显示，血浆和红细胞膜中亚油酸的比例降低。患者红细胞膜中的胆固醇含量明显减少。结果表明，这种异常与红细胞对过氧化应激的敏感性增强有关。本研究表明，除了红细胞抗氧化酶受损外，在研究脂质过氧化易感性增加的原因时，还应考虑膜脂质组成的异常。
