Silva Hellen Abreu da, Carraro Júlia Cristina Cardoso, Bressan Josefina, Hermsdorff Helen Hermana Miranda
Universidade Federal de Viçosa, Viçosa, MG, Brazil.
Einstein (Sao Paulo). 2015 Apr-Jun;13(2):202-8. doi: 10.1590/S1679-45082015AO3194. Epub 2015 May 19.
Objective To identify possible relations between serum uric acid levels and metabolic syndrome and its components in a population with cardiometabolic risk. Methods This cross-sectional study included 80 subjects (46 women), with mean age of 48±16 years, seen at the Cardiovascular Health Program. Results The prevalence of hyperuricemia and metabolic syndrome was 6.3% and 47.1%, respectively. Uric acid level was significantly higher in individuals with metabolic syndrome (5.1±1.6mg/dL), as compared to those with no syndrome or with pre-syndrome (3.9±1.2 and 4.1±1.3mg/dL, respectively; p<0.05). The uric acid levels were significantly higher in men presenting abdominal obesity, and among women with abdominal obesity, lower HDL-c levels and higher blood pressure (p<0.05). Conclusion Uric acid concentrations were positively related to the occurrence of metabolic syndrome and its components, and there were differences between genders. Our results indicate serum uric acid as a potential biomarker for patients with cardiometabolic risk.
目的 确定在有心脏代谢风险的人群中血清尿酸水平与代谢综合征及其组分之间的可能关系。方法 这项横断面研究纳入了80名受试者（46名女性），平均年龄为48±16岁，这些受试者来自心血管健康项目。结果 高尿酸血症和代谢综合征的患病率分别为6.3%和47.1%。与无综合征或有综合征前期的个体相比，代谢综合征患者的尿酸水平显著更高（分别为5.1±1.6mg/dL、3.9±1.2mg/dL和4.1±1.3mg/dL；p<0.05）。腹部肥胖的男性以及腹部肥胖、高密度脂蛋白胆固醇水平较低且血压较高的女性的尿酸水平显著更高（p<0.05）。结论 尿酸浓度与代谢综合征及其组分的发生呈正相关，且存在性别差异。我们的结果表明血清尿酸是有心脏代谢风险患者的潜在生物标志物。
