Zhang Xin, Ding Hui-Guo
Xin Zhang, Hui-Guo Ding, Department of Gastroenterology and Hepatology, Beijing You'an Hospital affiliated with Capital Medical University, Beijing 100069, China.
World J Hepatol. 2015 May 28;7(9):1282-6. doi: 10.4254/wjh.v7.i9.1282.
Chronic hepatitis B virus (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC). The HBV mutations, which include point mutation, deletion, insertion and truncation mutation of HBV gene in 4 open reading frames (S, C, P, X), are closely associated with HCC pathogenesis. Some mutations accumulated during chronic HBV infection could be regarded as a biomarker to predict the occurrence of HCC. The detection of the mutations in clinical practice could be helpful for defining better preventive and therapeutic strategies and, moreover, predicting the progression of liver disease.
慢性乙型肝炎病毒（HBV）感染是肝细胞癌（HCC）的主要危险因素。HBV突变包括HBV基因在4个开放阅读框（S、C、P、X）中的点突变、缺失、插入和截短突变，与HCC发病机制密切相关。慢性HBV感染过程中积累的一些突变可被视为预测HCC发生的生物标志物。在临床实践中检测这些突变有助于制定更好的预防和治疗策略，此外，还能预测肝病的进展。
