Stojanovic Slobodan, Jovanovic Marina, Vuckovic Nada
Department of Dermatology, Medical Faculty Novi Sad, University of Novi Sad, Novi Sad, Serbia.
Department of Pathology, Pathology and Histology Centre, Clinical Centre of Vojvodina, Medical Faculty Novi Sad, University of Novi Sad, Novi Sad, Serbia.
Iran Red Crescent Med J. 2015 Mar 31;17(3):e13478. doi: 10.5812/ircmj.13478. eCollection 2015 Mar.
Squamous cell carcinoma is the most common type of lip and oral cavity cancers. In majority of cases it follows quite common course, and after the surgery it does not produce any harm. This case presents unusual and unexpected growth of upper lip squamous cell carcinoma with severe cosmetic problems, and possible health threats.
A 46-year-old woman noticed on her upper lip "a spot, the size of a wheat grain", which grew rapidly and reached the size of 0.6 cm during a two-week period. The lesion was red, hard and painful, attached to the skin. It was surgically removed, and primary histopathological finding was follicular keratosis. Recurrent tumor appeared seven days after the operation, with the extreme swelling of the upper lip. The patient was sent to a tertiary hospital, where fungal or bacterial infection was excluded. The change on the patient's upper lip reached the size of 5 × 2 cm, as soft, reddish nodular tumor. Squamous cell carcinoma was diagnosed after the histopathological audit. With the second surgical intervention the tumor was removed and the defect reconstructed.
Prognosis of this type of tumor, apart from its size and differentiation level, depends on infiltration in tumor-surrounding tissue, perineural and perivascular spread. Therefore, it is always necessary to analyze the removed skin especially on margins.
鳞状细胞癌是唇部和口腔癌最常见的类型。在大多数情况下，其病程较为常见，手术后不会造成任何危害。本病例呈现出上唇鳞状细胞癌异常且意外的生长情况，伴有严重的美容问题以及可能的健康威胁。
一名46岁女性在上唇发现“一个麦粒大小的斑点”，其生长迅速，在两周内长到了0.6厘米大小。病变部位发红、坚硬且疼痛，与皮肤相连。该病变被手术切除，初步组织病理学检查结果为毛囊角化病。术后七天复发肿瘤出现，上唇极度肿胀。患者被送往三级医院，排除了真菌或细菌感染。患者上唇的病变发展到5×2厘米大小，为柔软的、微红的结节状肿瘤。经组织病理学检查后诊断为鳞状细胞癌。通过第二次手术干预，肿瘤被切除，缺损得以修复。
这类肿瘤的预后，除了其大小和分化程度外，还取决于肿瘤对周围组织的浸润、神经周围和血管周围的扩散情况。因此，始终有必要对切除的皮肤尤其是边缘部位进行分析。
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