Yang Yanzhou, Pei Xiuying, Jin Yaping, Wang Yanrong, Zhang Cheng
Key Laboratory of Fertility Preservation and Maintenance, Ministry of Education, Key Laboratory of Reproduction and Genetics in Ningxia, Department of Histology and Embryology, Ningxia Medical University, Yinchuan, Ningxia, 75004, People's Republic of China.
Key Laboratory of Animal Biotechnology of the Ministry of Agriculture, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Cell Tissue Res. 2016 Mar;363(3):589-97. doi: 10.1007/s00441-015-2212-x. Epub 2015 May 30.
Endoplasmic reticulum stress (ERS) activates a protective pathway, called the unfold protein response, for maintaining cellular homeostasis, but cellular apoptosis is triggered by excessive or persistent ERS. Several recent studies imply that the ERS response might have broader physiological roles in the various reproductive processes of female mammals, including embryo implantation, decidualization, preimplantation embryonic development, follicle atresia, and the development of the placenta. This review summarizes the existing data concerning the molecular and biological roles of the ERS response. The study of the functions of the ERS response in mammalian reproduction might provide novel insights into and an understanding of reproductive cell survival and apoptosis under physiological and pathological conditions. The ERS response is a novel signaling pathway for reproductive cell survival and apoptosis. Infertility might be a result of disturbing the ERS response during the process of female reproduction.
内质网应激（ERS）激活一种名为未折叠蛋白反应的保护途径，以维持细胞内稳态，但过度或持续的ERS会引发细胞凋亡。最近的几项研究表明，ERS反应可能在雌性哺乳动物的各种生殖过程中具有更广泛的生理作用，包括胚胎植入、蜕膜化、植入前胚胎发育、卵泡闭锁和胎盘发育。本综述总结了有关ERS反应的分子和生物学作用的现有数据。对ERS反应在哺乳动物生殖中的功能研究可能为生理和病理条件下生殖细胞的存活和凋亡提供新的见解和理解。ERS反应是生殖细胞存活和凋亡的一条新的信号通路。不孕症可能是女性生殖过程中干扰ERS反应的结果。
