Department of Biological Sciences, Center for Zebrafish Research, and Center for Stem Cells and Regenerative Medicine, University of Notre Dame, Notre Dame, IN 46556, USA.
Cells. 2015 May 27;4(2):218-33. doi: 10.3390/cells4020218.
The kidney is comprised of working units known as nephrons, which are epithelial tubules that contain a series of specialized cell types organized into a precise pattern of functionally distinct segment domains. There is a limited understanding of the genetic mechanisms that establish these discrete nephron cell types during renal development. The zebrafish embryonic kidney serves as a simplified yet conserved vertebrate model to delineate how nephron segments are patterned from renal progenitors. Here, we provide a concise review of recent advances in this emerging field, and discuss how continued research using zebrafish genetics can be applied to gain insights about nephrogenesis.
肾脏由称为肾单位的工作单位组成，这些单位是包含一系列特殊细胞类型的上皮小管，这些细胞类型按照精确的功能不同的节段域模式组织在一起。人们对在肾脏发育过程中建立这些离散的肾单位细胞类型的遗传机制的了解有限。斑马鱼胚胎肾是一种简化但保守的脊椎动物模型，用于描述肾祖细胞如何形成肾单位节段。在这里，我们对这一新兴领域的最新进展进行了简要回顾，并讨论了如何继续使用斑马鱼遗传学进行研究，以深入了解肾发生。
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