Krustev Eugene, Rioux Danielle, McDougall Jason J
Department of Pharmacology, Dalhousie University, 5850 College Street, Halifax, NS, B3H 4R2, Canada,
Curr Osteoporos Rep. 2015 Aug;13(4):216-24. doi: 10.1007/s11914-015-0275-y.
There are over 100 different types of arthritis and each can differ greatly in their aetiology and pathophysiology; however, one characteristic that is common to all arthritic conditions is joint pain. Musculoskeletal pain is the leading cause of disability in the world, and the number one reason arthritis patients visit their primary care physician. Despite the prevalence and burden of arthritis pain, current analgesics lack sufficient efficacy and are plagued by multiple adverse side effects. In this review, we outline the current landscape of research concerning joint pain, drawing from both preclinical and clinical studies. Specifically, this review is a discussion of the different neurophysiological processes that occur during joint disease and how inflammatory and neuropathic aspects contribute to the development of arthritis pain.
有100多种不同类型的关节炎，每种关节炎的病因和病理生理学都可能有很大差异；然而，所有关节炎病症共有的一个特征是关节疼痛。肌肉骨骼疼痛是全球致残的主要原因，也是关节炎患者就诊于初级保健医生的首要原因。尽管关节炎疼痛普遍存在且负担沉重，但目前的镇痛药缺乏足够的疗效，且受到多种不良副作用的困扰。在本综述中，我们从临床前和临床研究中提取信息，概述了当前关于关节疼痛的研究概况。具体而言，本综述讨论了关节疾病期间发生的不同神经生理过程，以及炎症和神经病变方面如何导致关节炎疼痛的发展。
