Xu Jiao-Ya, Zhang Li, Li Zhong-Ping, Ji Guang
Institute of Digestive Disease Shanghai University of Traditional Chinese Medicine, 725 south Wanping Road, Shanghai 200032, China.
Curr Drug Targets. 2015;16(12):1347-55. doi: 10.2174/1389450116666150531155711.
Non-alcoholic fatty liver disease (NAFLD) is a chronic disorder of lipid and carbohydrate metabolism and is often associated with endoplasmic reticulum stress, energy homeostasis dysregulation, and inflammation at cellular and molecular levels. Use of currently available anti-hyperlipidemia, hypoglycemia, or anti-inflammation drugs to treat NAFLD has not achieved desirable outcomes. A growing attention thus has been paid towards natural products as an alternative means in treating NALFD. Some of the natural products apparently possess the properties of ameliorating symptoms of NAFLD through restoration of lipid and carbohydrate metabolism and energy homeostasis. Data from recent animal and human studies concerning the use of natural products in the treatment of NAFLD are analyzed, and the potential underlying mechanisms are discussed.
非酒精性脂肪性肝病（NAFLD）是一种脂质和碳水化合物代谢的慢性紊乱疾病，常与内质网应激、能量稳态失调以及细胞和分子水平的炎症相关。使用目前可用的抗高脂血症、低血糖或抗炎药物治疗NAFLD尚未取得理想效果。因此，天然产物作为治疗NAFLD的替代手段越来越受到关注。一些天然产物显然具有通过恢复脂质和碳水化合物代谢以及能量稳态来改善NAFLD症状的特性。本文分析了近期关于使用天然产物治疗NAFLD的动物和人体研究数据，并讨论了潜在的作用机制。
