Gao Duo, Sun Xianlei, Gao Liquan, Liu Zhaofei
Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China.
Curr Drug Targets. 2015;16(6):634-44. doi: 10.2174/1389450116666150531155513.
Cancer-targeted radionuclide therapy is a promising approach for the treatment of a wide variety of malignancies, especially those resistant to conventional therapies. However, to improve the use of targeted radionuclide therapy for the management of cancer patients, the in vivo behaviors, dosimetry, and efficacy of radiotherapeutic agents need to be well characterized and monitored. Molecular imaging, which is a powerful tool for the noninvasive characterization and quantification of biological processes in living subjects at the cellular and molecular levels, plays an important role in the guidance of cancer radionuclide therapy. In this review, we introduce the radiotherapeutics for cancer-targeted therapy and summarize the most recent evidence supporting the use of molecular imaging to guide cancer radionuclide therapy.
癌症靶向放射性核素治疗是一种很有前景的治疗多种恶性肿瘤的方法，尤其是那些对传统疗法耐药的肿瘤。然而，为了更好地利用靶向放射性核素治疗癌症患者，需要对放射治疗剂的体内行为、剂量测定和疗效进行充分表征和监测。分子成像作为一种在细胞和分子水平上对活体生物过程进行无创表征和定量的强大工具，在癌症放射性核素治疗的指导中发挥着重要作用。在这篇综述中，我们介绍了用于癌症靶向治疗的放射治疗剂，并总结了支持使用分子成像来指导癌症放射性核素治疗的最新证据。
